Cell injury and death caused by bacterial protein toxins

Gianfranco Donelli, Carla Fiorentini

Research output: Contribution to journalArticlepeer-review


Bacterial protein toxins, such as Clostridium difficile toxin A and the Escherichia coli cytotoxic necrotizing factor 1 are known to exert their cytotoxic action via a modification of some cytoskeletal components. The changes in actin organization caused by these toxins appear to be the primary events in the mechanism leading to cell death.

Original languageEnglish
Pages (from-to)695-699
Number of pages5
JournalToxicology Letters
Issue numberC
Publication statusPublished - 1992


  • Clostridium difficile toxin A
  • Cytoskeleton
  • Cytotoxicity
  • Escherichia coli CNF1

ASJC Scopus subject areas

  • Toxicology


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