Cell kinetics and hormonal features in relation to pathological stage in breast cancer

Dino Amadori, Chiara Bonaguri, Oriana Nanni, Patrizia Gentilini, Nadia Lundi, Wainer Zoli, Angela Riccobon, Antonio Vio, Enrico Magni, Ariele Saragoni

Research output: Contribution to journalArticlepeer-review

Abstract

Proliferative activity (expressed as3H-thymidine labeling index,3H-TdR LI) was evaluated on a series of 281 primary tumors recruited in two years in 6 different institutions from central Italy.3H-TdR LI proved to be low in intraductal, or well and moderately differentiated, or hormone receptor positive tumors. Conversely, no relation was observed between3H-TdR LI and menopause, tumor size, or lymph node involvement. An inverse relation was observed between3H-TdR LI and hormone receptor content. Specific patterns of3H-TdR LI value and ER content association were observed as a function of menopause, lymph nodal status, and degree of lymph nodal involvement.

Original languageEnglish
Pages (from-to)19-25
Number of pages7
JournalBreast Cancer Research and Treatment
Volume18
Issue number1
DOIs
Publication statusPublished - Mar 1991

Keywords

  • estrogen receptors
  • progesterone receptors
  • prognostic factors
  • proliferative rate
  • thymidine labeling index

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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