Cell kinetics and hormonal features in relation to pathological stage in breast cancer

Dino Amadori; Chiara Bonaguri; Oriana Nanni; Patrizia Gentilini; Nadia Lundi; Wainer Zoli; Angela Riccobon; Antonio Vio; Enrico Magni; Ariele Saragoni

doi:10.1007/BF01975439

Cell kinetics and hormonal features in relation to pathological stage in breast cancer

Dino Amadori, Chiara Bonaguri, Oriana Nanni, Patrizia Gentilini, Nadia Lundi, Wainer Zoli, Angela Riccobon, Antonio Vio, Enrico Magni, Ariele Saragoni

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

Proliferative activity (expressed as³H-thymidine labeling index,³H-TdR LI) was evaluated on a series of 281 primary tumors recruited in two years in 6 different institutions from central Italy.³H-TdR LI proved to be low in intraductal, or well and moderately differentiated, or hormone receptor positive tumors. Conversely, no relation was observed between³H-TdR LI and menopause, tumor size, or lymph node involvement. An inverse relation was observed between³H-TdR LI and hormone receptor content. Specific patterns of³H-TdR LI value and ER content association were observed as a function of menopause, lymph nodal status, and degree of lymph nodal involvement.

Original language	English
Pages (from-to)	19-25
Number of pages	7
Journal	Breast Cancer Research and Treatment
Volume	18
Issue number	1
DOIs	https://doi.org/10.1007/BF01975439
Publication status	Published - Mar 1991

Keywords

estrogen receptors
progesterone receptors
prognostic factors
proliferative rate
thymidine labeling index

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1007/BF01975439

Cite this

Cell kinetics and hormonal features in relation to pathological stage in breast cancer. / Amadori, Dino; Bonaguri, Chiara; Nanni, Oriana; Gentilini, Patrizia; Lundi, Nadia; Zoli, Wainer; Riccobon, Angela; Vio, Antonio; Magni, Enrico; Saragoni, Ariele.

In: Breast Cancer Research and Treatment, Vol. 18, No. 1, 03.1991, p. 19-25.

Research output: Contribution to journal › Article › peer-review

@article{ffe78e9ed9004a1d8258b912ca06d2c0,

title = "Cell kinetics and hormonal features in relation to pathological stage in breast cancer",

abstract = "Proliferative activity (expressed as3H-thymidine labeling index,3H-TdR LI) was evaluated on a series of 281 primary tumors recruited in two years in 6 different institutions from central Italy.3H-TdR LI proved to be low in intraductal, or well and moderately differentiated, or hormone receptor positive tumors. Conversely, no relation was observed between3H-TdR LI and menopause, tumor size, or lymph node involvement. An inverse relation was observed between3H-TdR LI and hormone receptor content. Specific patterns of3H-TdR LI value and ER content association were observed as a function of menopause, lymph nodal status, and degree of lymph nodal involvement.",

keywords = "estrogen receptors, progesterone receptors, prognostic factors, proliferative rate, thymidine labeling index",

author = "Dino Amadori and Chiara Bonaguri and Oriana Nanni and Patrizia Gentilini and Nadia Lundi and Wainer Zoli and Angela Riccobon and Antonio Vio and Enrico Magni and Ariele Saragoni",

year = "1991",

month = mar,

doi = "10.1007/BF01975439",

language = "English",

volume = "18",

pages = "19--25",

journal = "Breast Cancer Research and Treatment",

issn = "0167-6806",

publisher = "Springer New York LLC",

number = "1",

}

TY - JOUR

T1 - Cell kinetics and hormonal features in relation to pathological stage in breast cancer

AU - Amadori, Dino

AU - Bonaguri, Chiara

AU - Nanni, Oriana

AU - Gentilini, Patrizia

AU - Lundi, Nadia

AU - Zoli, Wainer

AU - Riccobon, Angela

AU - Vio, Antonio

AU - Magni, Enrico

AU - Saragoni, Ariele

PY - 1991/3

Y1 - 1991/3

N2 - Proliferative activity (expressed as3H-thymidine labeling index,3H-TdR LI) was evaluated on a series of 281 primary tumors recruited in two years in 6 different institutions from central Italy.3H-TdR LI proved to be low in intraductal, or well and moderately differentiated, or hormone receptor positive tumors. Conversely, no relation was observed between3H-TdR LI and menopause, tumor size, or lymph node involvement. An inverse relation was observed between3H-TdR LI and hormone receptor content. Specific patterns of3H-TdR LI value and ER content association were observed as a function of menopause, lymph nodal status, and degree of lymph nodal involvement.

AB - Proliferative activity (expressed as3H-thymidine labeling index,3H-TdR LI) was evaluated on a series of 281 primary tumors recruited in two years in 6 different institutions from central Italy.3H-TdR LI proved to be low in intraductal, or well and moderately differentiated, or hormone receptor positive tumors. Conversely, no relation was observed between3H-TdR LI and menopause, tumor size, or lymph node involvement. An inverse relation was observed between3H-TdR LI and hormone receptor content. Specific patterns of3H-TdR LI value and ER content association were observed as a function of menopause, lymph nodal status, and degree of lymph nodal involvement.

KW - estrogen receptors

KW - progesterone receptors

KW - prognostic factors

KW - proliferative rate

KW - thymidine labeling index

UR - http://www.scopus.com/inward/record.url?scp=0025765377&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025765377&partnerID=8YFLogxK

U2 - 10.1007/BF01975439

DO - 10.1007/BF01975439

M3 - Article

C2 - 1854976

AN - SCOPUS:0025765377

VL - 18

SP - 19

EP - 25

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

SN - 0167-6806

IS - 1

ER -

Cell kinetics and hormonal features in relation to pathological stage in breast cancer

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this