Cell kinetics and prognosis in gastric cancer

D. Amadori, C. Bonaguri, A. Volpi, O. Nanni, W. Zoli, N. Lundi, A. Amadori, E. Magni, A. Saragoni

Research output: Contribution to journalArticlepeer-review

Abstract

Methods. The potential proliferative activity of primary gastric cancer was determined using the in vitro tritiated thymidine labeling index (LI) technique. Results. The proliferative rate had a wide range (0.1-28.4%) with a median value of 9.3%. The cell kinetics of the primary tumor were not related to clinicopathologic features, such as the patient's age and sex or the tumor's histologic type and stage. The contribution of cell kinetics to prognosis was investigated in a series of 28 patients (median follow-up, 34 months). The 3-year survival rate was 50% for patients with slowly proliferating tumors compared with only 13% for those with rapidly proliferating tumors. Moreover, in patients with high-LI tumors, the risk of death was more than sixfold greater than for those with low-LI tumors. Conclusions. These data suggest that cell kinetic studies might be an important discriminant to predict prognosis in gastric cancer.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalCancer
Volume71
Issue number1
DOIs
Publication statusPublished - 1993

Keywords

  • cell kinetics
  • gastric cancer
  • prognosis
  • thymidine labeling index

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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