Cell kinetics and tumor regression during radiotherapy in head and neck squamous-cell carcinomas

Renzo Corvò, Walter Giaretti, Elio Geido, Giuseppe Sanguineti, Roberto Orecchia, Marco Scala, Giacomo Garaventa, Enzo Mora, Vito Vitale

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Head and neck squamous-cell carcinoma (HN-SCC) patient management is mainly based on TNM classification and needs be improved by considering other potentially useful prognostic factors. We examined the pre-radiotherapy tumor potential doubling time (T(pot) evaluated after in vivo infusion of bromodeoxyuridine and flow-cytometric analysis and the early clinical tumor regression after 40 Gy (40 Gy-TR). T(pot) values and clinical 40 Gy-TR classes (minor and major) were available for 82 HN-SCC patients. Radiation therapy completion was done either with 1 dose per day (conventional regimen) or 2 doses per day (accelerated regimen). Local central was also available for follow-up times above 4 years. We found that major 40 Gy-TR was strongly correlated with fast tumor growth, characterized by T(pot) values below 5 days, and that patients with major 40 Gy-TR showed better local control than those with minor 40 Gy-TR, independently from the radiotherapy regimen type. We also found that treatment completion with accelerated radiotherapy gave better local control for patients with major 40 Gy-TR and fast tumor growth than conventional radiotherapy. Multivariate analysis, performed on all patients, assigned an independent prognostic value to T(pot), tumor classification and 40 Gy-TR.

Original languageEnglish
Pages (from-to)151-155
Number of pages5
JournalInternational Journal of Cancer
Issue number2
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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