Cell kinetics as a prognostic indicator in node-negative breast cancer

R. Silvestrini, M. G. Daidone, P. Valagussa, G. Di Fronzo, G. Mezzanotte, G. Bonadonna

Research output: Contribution to journalArticle

Abstract

The consistency of the prognostic role of cell kinetics (evaluated as the [3H]thymidine labeling index, LI) over a period of years has been assessed in 354 patients with resectable node-negative breast cancer subjected only to Halsted or modified radical mastectomy. The risk of disease recurrence and death was proportional to LI values and the pattern was superimposable, regardless of menopausal status, in the two consecutive case series entered in this retrospective study. In particular, tumors with high LI (>2.8%) had a higher 6-year probability (41% vs. 25%, P <0.0001) of manifesting local-regional and distant metastases and of dying (19% vs. 5%, P = 0.0005) as compared to tumors with low LI. In tumors with high LI the risk of relapse within the first 2 years from mastectomy was twofold compared to that of tumors with low LI. Multiple regression analysis showed that LI also retained its prognostic significance in both relapse-free and overall survival when tumor size and estrogen receptor status were considered. The present findings confirm that LI can substantially contribute to the selection of high risk node-negative patients who could be candidates for adjuvant chemotherapy.

Original languageEnglish
Pages (from-to)1165-1171
Number of pages7
JournalEuropean Journal of Cancer and Clinical Oncology
Volume25
Issue number8
DOIs
Publication statusPublished - 1989

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Breast Neoplasms
Neoplasms
Recurrence
Modified Radical Mastectomy
Mastectomy
Adjuvant Chemotherapy
Estrogen Receptors
Thymidine
Retrospective Studies
Regression Analysis
Neoplasm Metastasis
Survival

ASJC Scopus subject areas

  • Oncology

Cite this

Cell kinetics as a prognostic indicator in node-negative breast cancer. / Silvestrini, R.; Daidone, M. G.; Valagussa, P.; Di Fronzo, G.; Mezzanotte, G.; Bonadonna, G.

In: European Journal of Cancer and Clinical Oncology, Vol. 25, No. 8, 1989, p. 1165-1171.

Research output: Contribution to journalArticle

Silvestrini, R. ; Daidone, M. G. ; Valagussa, P. ; Di Fronzo, G. ; Mezzanotte, G. ; Bonadonna, G. / Cell kinetics as a prognostic indicator in node-negative breast cancer. In: European Journal of Cancer and Clinical Oncology. 1989 ; Vol. 25, No. 8. pp. 1165-1171.
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AU - Bonadonna, G.

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