Cell kinetics in ovarian cancer. Relationship to clinicopathologic features, responsiveness to chemotherapy, and survival

P. F. Conte, A. Alama, A. Rubagotti, S. Chiara, A. Nicolin, G. Nicolo, R. Rosso, M. Gaddi, B. Ghiringhello, S. Tomao, G. Foglia, N. Ragni

Research output: Contribution to journalArticlepeer-review

Abstract

The tumor proliferative activity of 74 previously untreated epithelial ovarian carcinomas was evaluated by the thymidine labeling index (TLI) and the primer-dependent alpha DNA polymerase assay (PDP-LI). The median TLI and PDP-LI were 2% (0.1 to 28.0) and 10% (3.0 to 80.0%), respectively. The TLI was significantly correlated to tumor grade, International Federation of Gynecology and Obstetrics (FIGO) stage, and residual disease. However, neither the TLI nor the PDP-LI was a predictor of survival. A higher response rate was observed in the case of rapidly proliferating tumors: an objective response (OR) was observed in 38.4% of the patients with a low TLI and in 53.6% of the patients with a high TLI. The advantage of an OR in favor of the high TLI group was significant for patients treated with regimens containing doxorubicin (high TLI, 72.2% OR; low TLI, 40% OR; P = 0.03).

Original languageEnglish
Pages (from-to)1188-1191
Number of pages4
JournalCancer
Volume64
Issue number6
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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