Cell loss and proliferation in non-small cell lung carcinoma: Correlation with histological subtype

F. Mangili, C. Cigala, G. Arrigoni, E. Rovere, C. Gattuso, G. Santambrogio, P. Garancini

Research output: Contribution to journalArticle

Abstract

Background: Cell kinetic data are important indicators of the aggressiveness of tumor and treatment response. The size of a neoplasm depends on the balance between cell proliferation and death. Thus, the analysis of the kinetics of cell proliferation and death may explain differences in the rates of tumour progression. Methods: We studied apoptosis and proliferative indices in 95 cases of non-small cell lung carcinomas. The analysis was performed on paraffin-embedded tissue, by both MIB-1 immunocytochemical detection to establish the proliferation index and the in-situ end labelling method for the apoptosis index. The two indices were related. Results: Our results showed a high proliferative index and cell loss rate in squamous cell carcinoma, and a low proliferative index and cell loss rate in adenocarcinoma, suggesting two different growth patterns. Conclusion: These findings could explain the different biological behaviour and treatment response of the tumours. The tendency of a cancer cell to undergo apoptosis may be especially important for the chemotherapy of malignant tumours with a low growth rate, which are typically resistant to cytostatic agents.

Original languageEnglish
Pages (from-to)287-295
Number of pages9
JournalEuropean journal of histochemistry : EJH
Volume42
Issue number4
Publication statusPublished - 1998

Keywords

  • Apoptosis
  • Cell proliferation
  • Immunohistochemistry
  • Non-small cell lung carcinoma

ASJC Scopus subject areas

  • Cell Biology
  • Anatomy
  • Animal Science and Zoology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Cell loss and proliferation in non-small cell lung carcinoma: Correlation with histological subtype'. Together they form a unique fingerprint.

  • Cite this

    Mangili, F., Cigala, C., Arrigoni, G., Rovere, E., Gattuso, C., Santambrogio, G., & Garancini, P. (1998). Cell loss and proliferation in non-small cell lung carcinoma: Correlation with histological subtype. European journal of histochemistry : EJH, 42(4), 287-295.