Abstract
Peripheral blood mononuclear cells (PBMC) from 16 non-institutionalized patients with Down syndrome (DS) were studied with various monoclonal antibodies and analysed for natural killer (NK), and NK-like activity. Lymphocyte proliferation and cytotoxic T-lymphocyte (CTL) cytotoxicity generated in mixed lymphocyte culture (MLC) were also evaluated in 11 DS patients. Phenotypic characterization of PBMC from DS subjects confirms our previous findings of high numbers of CD8+ lymphocytes and HNK-1+, and CD16+ cells. Lymphocyte proliferation and CTL cytotoxicity generated in MLC were low or absent in most patients. NK activity was low in almost all DS patients, while NK-like cytotoxicity generated in MLC was normal in the majority and did not correlate with NK activity from unstimulated PBMC.
| Original language | English |
|---|---|
| Pages (from-to) | 53-57 |
| Number of pages | 5 |
| Journal | European Journal of Pediatrics |
| Volume | 148 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Oct 1988 |
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Keywords
- Down syndrome
- Immunodeficiency
- Mixed lymphocyte reaction
- NK activity
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Cell-mediated cytotoxicity in down syndrome : impairment of allogeneic mixed lymphocyte reaction, NK and NK-like activities. / Montagna, D.; Maccario, R.; Ugazio, A. G.; Nespoli, L.; Pedroni, E.; Faggiano, P.; Burgio, G. R.
In: European Journal of Pediatrics, Vol. 148, No. 1, 10.1988, p. 53-57.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cell-mediated cytotoxicity in down syndrome
T2 - impairment of allogeneic mixed lymphocyte reaction, NK and NK-like activities
AU - Montagna, D.
AU - Maccario, R.
AU - Ugazio, A. G.
AU - Nespoli, L.
AU - Pedroni, E.
AU - Faggiano, P.
AU - Burgio, G. R.
PY - 1988/10
Y1 - 1988/10
N2 - Peripheral blood mononuclear cells (PBMC) from 16 non-institutionalized patients with Down syndrome (DS) were studied with various monoclonal antibodies and analysed for natural killer (NK), and NK-like activity. Lymphocyte proliferation and cytotoxic T-lymphocyte (CTL) cytotoxicity generated in mixed lymphocyte culture (MLC) were also evaluated in 11 DS patients. Phenotypic characterization of PBMC from DS subjects confirms our previous findings of high numbers of CD8+ lymphocytes and HNK-1+, and CD16+ cells. Lymphocyte proliferation and CTL cytotoxicity generated in MLC were low or absent in most patients. NK activity was low in almost all DS patients, while NK-like cytotoxicity generated in MLC was normal in the majority and did not correlate with NK activity from unstimulated PBMC.
AB - Peripheral blood mononuclear cells (PBMC) from 16 non-institutionalized patients with Down syndrome (DS) were studied with various monoclonal antibodies and analysed for natural killer (NK), and NK-like activity. Lymphocyte proliferation and cytotoxic T-lymphocyte (CTL) cytotoxicity generated in mixed lymphocyte culture (MLC) were also evaluated in 11 DS patients. Phenotypic characterization of PBMC from DS subjects confirms our previous findings of high numbers of CD8+ lymphocytes and HNK-1+, and CD16+ cells. Lymphocyte proliferation and CTL cytotoxicity generated in MLC were low or absent in most patients. NK activity was low in almost all DS patients, while NK-like cytotoxicity generated in MLC was normal in the majority and did not correlate with NK activity from unstimulated PBMC.
KW - Down syndrome
KW - Immunodeficiency
KW - Mixed lymphocyte reaction
KW - NK activity
UR - http://www.scopus.com/inward/record.url?scp=0023683210&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023683210&partnerID=8YFLogxK
U2 - 10.1007/BF00441815
DO - 10.1007/BF00441815
M3 - Article
C2 - 2973987
AN - SCOPUS:0023683210
VL - 148
SP - 53
EP - 57
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
SN - 0340-6199
IS - 1
ER -