Cell-mediated immunity in children with chronic cholestasis

Giuseppe Maggiore, Costantino de Giacomo, Maria Serenella Scotta, Salvatore Siena, Rita Maccario, Antonella Vitiello

Research output: Contribution to journalArticlepeer-review


Cell mediated immune response was evaluated in 14 children with long-lasting intra-or extrahepatic cholestasis. Cell-mediated immunity was clearly depressed in children with intrahepatic cholestasis while children with extrahepatic biliary obstruction had a more modest and variable degree of impairment. This finding may be related to the longer duration of cholcstasis and the higher total bile acid level in the intrahepatic compared to the extrahepatic group. In particular, in children with Byler disease, long-lasting, severe intrahepatic cholestasis was associated with depressed cell-mediated immunity and recurrent severe infections.

Original languageEnglish
Pages (from-to)385-388
Number of pages4
JournalJournal of Pediatric Gastroenterology and Nutrition
Issue number3
Publication statusPublished - 1982


  • Cell-mediated immunity
  • Children
  • Chronic cholestasis

ASJC Scopus subject areas

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health
  • Histology
  • Medicine (miscellaneous)
  • Food Science


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