Cell-mediated immunity in children with chronic cholestasis

Giuseppe Maggiore, Costantino de Giacomo, Maria Serenella Scotta, Salvatore Siena, Rita Maccario, Antonella Vitiello

Research output: Contribution to journalArticle

Abstract

Cell mediated immune response was evaluated in 14 children with long-lasting intra-or extrahepatic cholestasis. Cell-mediated immunity was clearly depressed in children with intrahepatic cholestasis while children with extrahepatic biliary obstruction had a more modest and variable degree of impairment. This finding may be related to the longer duration of cholcstasis and the higher total bile acid level in the intrahepatic compared to the extrahepatic group. In particular, in children with Byler disease, long-lasting, severe intrahepatic cholestasis was associated with depressed cell-mediated immunity and recurrent severe infections.

Original languageEnglish
Pages (from-to)385-388
Number of pages4
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume1
Issue number3
Publication statusPublished - 1982

Fingerprint

cholestasis
Cholestasis
Cellular Immunity
cell-mediated immunity
Intrahepatic Cholestasis
Extrahepatic Cholestasis
bile acids
Bile Acids and Salts
duration
Infection
infection
intrahepatic cholestasis

Keywords

  • Cell-mediated immunity
  • Children
  • Chronic cholestasis

ASJC Scopus subject areas

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health
  • Histology
  • Medicine (miscellaneous)
  • Food Science

Cite this

Maggiore, G., de Giacomo, C., Scotta, M. S., Siena, S., Maccario, R., & Vitiello, A. (1982). Cell-mediated immunity in children with chronic cholestasis. Journal of Pediatric Gastroenterology and Nutrition, 1(3), 385-388.

Cell-mediated immunity in children with chronic cholestasis. / Maggiore, Giuseppe; de Giacomo, Costantino; Scotta, Maria Serenella; Siena, Salvatore; Maccario, Rita; Vitiello, Antonella.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 1, No. 3, 1982, p. 385-388.

Research output: Contribution to journalArticle

Maggiore, G, de Giacomo, C, Scotta, MS, Siena, S, Maccario, R & Vitiello, A 1982, 'Cell-mediated immunity in children with chronic cholestasis', Journal of Pediatric Gastroenterology and Nutrition, vol. 1, no. 3, pp. 385-388.
Maggiore G, de Giacomo C, Scotta MS, Siena S, Maccario R, Vitiello A. Cell-mediated immunity in children with chronic cholestasis. Journal of Pediatric Gastroenterology and Nutrition. 1982;1(3):385-388.
Maggiore, Giuseppe ; de Giacomo, Costantino ; Scotta, Maria Serenella ; Siena, Salvatore ; Maccario, Rita ; Vitiello, Antonella. / Cell-mediated immunity in children with chronic cholestasis. In: Journal of Pediatric Gastroenterology and Nutrition. 1982 ; Vol. 1, No. 3. pp. 385-388.
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