Cell-Penetrating Peptides: From Basic Research to Clinics

Giulia Guidotti, Liliana Brambilla, Daniela Rossi

Research output: Contribution to journalReview articlepeer-review

Abstract

The presence of cell and tissue barriers together with the low biomembrane permeability of various therapeutics often hampers systemic drug distribution; thus, most of the available molecules are of limited therapeutic value. Opportunities to increase medicament concentrations in areas that are difficult to access now exist with the advent of cell-penetrating peptides (CPPs), which can transport into the cell a wide variety of biologically active conjugates (cargoes). Numerous preclinical evaluations with CPP-derived therapeutics have provided promising results in various disease models that, in some cases, prompted clinical trials. The outcome of these investigations has thus opened new perspectives for CPP application in the development of unprecedented human therapies that are well tolerated and directed to intracellular targets.

Original languageEnglish
Pages (from-to)406-424
Number of pages19
JournalTrends in Pharmacological Sciences
Volume38
Issue number4
DOIs
Publication statusPublished - Apr 2017

Keywords

  • Journal Article
  • Review

Fingerprint Dive into the research topics of 'Cell-Penetrating Peptides: From Basic Research to Clinics'. Together they form a unique fingerprint.

Cite this