Cell permeable peptides: A promising tool to deliver neuroprotective agents in the brain

Xanthi Antoniou, Tiziana Borsello

Research output: Contribution to journalArticlepeer-review

Abstract

The inability of most drugs to cross the blood-brain barrier and/or plasma membrane limits their use for biomedical applications in the brain. Cell Permeable Peptides (CPPs) overcome this problem and are effective in vivo, crossing the plasma membrane and the blood-brain barrier. CPPs deliver a wide variety of compounds intracellularly in an active form. In fact, many bioactive cargoes have neuroprotective properties, and due to their ability to block protein-protein interactions, offer exciting perspectives in the clinical setting. In this review we give an overview of the Cell Permeable Peptides strategy to deliver neuroprotectants against neurodegeneration in the CNS.

Original languageEnglish
Pages (from-to)379-392
Number of pages14
JournalPharmaceuticals
Volume3
Issue number2
DOIs
Publication statusPublished - 2010

Keywords

  • Brain
  • CPPs
  • Drug discovery
  • Neuroprotection
  • Protein-protein interaction

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science

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