Cell regeneration in the pathobiology of liver carcinomas

A. Francavilla, M. Barone, A. Azzarone, C. Panella, A. Giangaspero

Research output: Contribution to journalArticlepeer-review


It is known that there is a close relationship between cirrhosis and liver cancer. The proliferative phenomena characterizing liver cirrhosis seem to be predisposing factors for carcinoma. In fact, they differ from the self-limiting proliferative phenomena occurring in normal liver regeneration because they are associated with: 1) an abnormal hormonal pattern; 2) an altered arrangement of hepatocytes and non-parenchymal cells within the lobule; 3) an altered production of growth factors able to modulate liver regeneration; and 4) an abnormal oncogene expression. Under such conditions many carcinogens, which require the target cell to be in a replicative phase, have the opportunity to act.

Original languageEnglish
Pages (from-to)589-593
Number of pages5
JournalItalian Journal of Gastroenterology
Issue number9
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Gastroenterology


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