Cell reprogramming: A new chemical approach to stem cell biology and tissue regeneration

L. Anastasia, M. Piccoli, A. Garatti, E. Conforti, R. Scaringi, S. Bergante, S. Castelvecchio, B. Venerando, L. Menicanti, G. Tettamanti

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Generation of pluripotent stem cells (iPSCs) from adult fibroblasts starts a "new era" in stem cell biology, as it overcomes several key issues associated with previous approaches, including the ethical concerns associated with human embryonic stem cells. However, as the genetic approach for cell reprogramming has already shown potential safety issues, a chemical approach may be a safer and easier alternative. Moreover, a chemical approach could be advantageous not only for the de-differentiation phase, but also for inducing reprogrammed cells into the desired cell type with higher efficiency than current methodologies. Finally, a chemical approach may be envisioned to activate resident adult stem cells to proliferate and regenerate damaged tissues in situ, without the need for exogenous cell injections.

Original languageEnglish
Pages (from-to)146-150
Number of pages5
JournalCurrent Pharmaceutical Biotechnology
Volume12
Issue number2
Publication statusPublished - 2011

Fingerprint

Cell Biology
Regeneration
Stem Cells
Pluripotent Stem Cells
Adult Stem Cells
Fibroblasts
Safety
Injections
Cellular Reprogramming
Human Embryonic Stem Cells

Keywords

  • Chemical molecules reprogramming stem cell
  • Stem cell
  • Tissue regeneration

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Biotechnology

Cite this

Cell reprogramming : A new chemical approach to stem cell biology and tissue regeneration. / Anastasia, L.; Piccoli, M.; Garatti, A.; Conforti, E.; Scaringi, R.; Bergante, S.; Castelvecchio, S.; Venerando, B.; Menicanti, L.; Tettamanti, G.

In: Current Pharmaceutical Biotechnology, Vol. 12, No. 2, 2011, p. 146-150.

Research output: Contribution to journalArticle

@article{e778830600d04b078b40fdd23853faeb,
title = "Cell reprogramming: A new chemical approach to stem cell biology and tissue regeneration",
abstract = "Generation of pluripotent stem cells (iPSCs) from adult fibroblasts starts a {"}new era{"} in stem cell biology, as it overcomes several key issues associated with previous approaches, including the ethical concerns associated with human embryonic stem cells. However, as the genetic approach for cell reprogramming has already shown potential safety issues, a chemical approach may be a safer and easier alternative. Moreover, a chemical approach could be advantageous not only for the de-differentiation phase, but also for inducing reprogrammed cells into the desired cell type with higher efficiency than current methodologies. Finally, a chemical approach may be envisioned to activate resident adult stem cells to proliferate and regenerate damaged tissues in situ, without the need for exogenous cell injections.",
keywords = "Chemical molecules reprogramming stem cell, Stem cell, Tissue regeneration",
author = "L. Anastasia and M. Piccoli and A. Garatti and E. Conforti and R. Scaringi and S. Bergante and S. Castelvecchio and B. Venerando and L. Menicanti and G. Tettamanti",
year = "2011",
language = "English",
volume = "12",
pages = "146--150",
journal = "Current Pharmaceutical Biotechnology",
issn = "1389-2010",
publisher = "Bentham Science Publishers B.V.",
number = "2",

}

TY - JOUR

T1 - Cell reprogramming

T2 - A new chemical approach to stem cell biology and tissue regeneration

AU - Anastasia, L.

AU - Piccoli, M.

AU - Garatti, A.

AU - Conforti, E.

AU - Scaringi, R.

AU - Bergante, S.

AU - Castelvecchio, S.

AU - Venerando, B.

AU - Menicanti, L.

AU - Tettamanti, G.

PY - 2011

Y1 - 2011

N2 - Generation of pluripotent stem cells (iPSCs) from adult fibroblasts starts a "new era" in stem cell biology, as it overcomes several key issues associated with previous approaches, including the ethical concerns associated with human embryonic stem cells. However, as the genetic approach for cell reprogramming has already shown potential safety issues, a chemical approach may be a safer and easier alternative. Moreover, a chemical approach could be advantageous not only for the de-differentiation phase, but also for inducing reprogrammed cells into the desired cell type with higher efficiency than current methodologies. Finally, a chemical approach may be envisioned to activate resident adult stem cells to proliferate and regenerate damaged tissues in situ, without the need for exogenous cell injections.

AB - Generation of pluripotent stem cells (iPSCs) from adult fibroblasts starts a "new era" in stem cell biology, as it overcomes several key issues associated with previous approaches, including the ethical concerns associated with human embryonic stem cells. However, as the genetic approach for cell reprogramming has already shown potential safety issues, a chemical approach may be a safer and easier alternative. Moreover, a chemical approach could be advantageous not only for the de-differentiation phase, but also for inducing reprogrammed cells into the desired cell type with higher efficiency than current methodologies. Finally, a chemical approach may be envisioned to activate resident adult stem cells to proliferate and regenerate damaged tissues in situ, without the need for exogenous cell injections.

KW - Chemical molecules reprogramming stem cell

KW - Stem cell

KW - Tissue regeneration

UR - http://www.scopus.com/inward/record.url?scp=79551626698&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79551626698&partnerID=8YFLogxK

M3 - Article

C2 - 21044013

AN - SCOPUS:79551626698

VL - 12

SP - 146

EP - 150

JO - Current Pharmaceutical Biotechnology

JF - Current Pharmaceutical Biotechnology

SN - 1389-2010

IS - 2

ER -