Cell surface proteins in hepatocellular carcinoma: From bench to bedside

Gabriel Siracusano, Mariella Tagliamonte, Luigi Buonaguro, Lucia Lopalco

Research output: Contribution to journalReview articlepeer-review

Abstract

Cell surface proteins act as the go-between in carrying the information from the extracellular environment to the intracellular signaling proteins. However, these proteins are often deregulated in neoplastic diseases, including hepatocellular carcinoma. This review discusses several recent studies that have investigated the role of cell surface proteins in the occurrence and progression of HCC, highlighting the possibility to use them as biomarkers of the disease and/or targets for vaccines and therapeutics.

Original languageEnglish
Article number41
JournalVaccines
Volume8
Issue number1
DOIs
Publication statusPublished - Mar 2020

Keywords

  • Biomarker
  • Cell surface proteins
  • Clinical trial
  • Hepatocellular carcinoma
  • Therapeutic target

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Drug Discovery
  • Infectious Diseases
  • Pharmacology (medical)

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