Cell therapies in neuro-oncology

S. Pellegatta; G. Finocchiaro

doi:10.1007/s10072-005-0405-x

Cell therapies in neuro-oncology

S. Pellegatta, G. Finocchiaro

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article

Abstract

During their growth, malignant gliomas interact with the immune system and are able to escape immune reactions. Attempts to instruct the immune system to develop anti-glioma reactions have been partly unsuccessful. Recent advances in the molecular and cellular biology of dendritic cells (DC), however, may increase the chances of preparing effective "vaccines" against these tumours. We show that vaccination with DC pulsed with a tumour lysate considerably increases survival in mice bearing intracranial glioblastomas. These results support the development of DC-based clinical trials for patients with glioblastomas that do not respond to standard therapies.

Original language	English
Journal	Neurological Sciences
Volume	26
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1007/s10072-005-0405-x
Publication status	Published - May 2005

Fingerprint

Keywords

Dendritic cells
Glioma
Immunotherapy

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

Cite this

Pellegatta, S., & Finocchiaro, G. (2005). Cell therapies in neuro-oncology. Neurological Sciences, 26(SUPPL. 1). https://doi.org/10.1007/s10072-005-0405-x

@article{9ffb22cf0aa34e4db0e2d2aa83709d2e,

title = "Cell therapies in neuro-oncology",

abstract = "During their growth, malignant gliomas interact with the immune system and are able to escape immune reactions. Attempts to instruct the immune system to develop anti-glioma reactions have been partly unsuccessful. Recent advances in the molecular and cellular biology of dendritic cells (DC), however, may increase the chances of preparing effective {"}vaccines{"} against these tumours. We show that vaccination with DC pulsed with a tumour lysate considerably increases survival in mice bearing intracranial glioblastomas. These results support the development of DC-based clinical trials for patients with glioblastomas that do not respond to standard therapies.",

keywords = "Dendritic cells, Glioma, Immunotherapy",

author = "S. Pellegatta and G. Finocchiaro",

year = "2005",

month = may

doi = "10.1007/s10072-005-0405-x",

language = "English",

volume = "26",

journal = "Neurological Sciences",

issn = "1590-1874",

publisher = "Springer-Verlag Italia s.r.l.",

number = "SUPPL. 1",

}

TY - JOUR

T1 - Cell therapies in neuro-oncology

AU - Pellegatta, S.

AU - Finocchiaro, G.

PY - 2005/5

Y1 - 2005/5

N2 - During their growth, malignant gliomas interact with the immune system and are able to escape immune reactions. Attempts to instruct the immune system to develop anti-glioma reactions have been partly unsuccessful. Recent advances in the molecular and cellular biology of dendritic cells (DC), however, may increase the chances of preparing effective "vaccines" against these tumours. We show that vaccination with DC pulsed with a tumour lysate considerably increases survival in mice bearing intracranial glioblastomas. These results support the development of DC-based clinical trials for patients with glioblastomas that do not respond to standard therapies.

AB - During their growth, malignant gliomas interact with the immune system and are able to escape immune reactions. Attempts to instruct the immune system to develop anti-glioma reactions have been partly unsuccessful. Recent advances in the molecular and cellular biology of dendritic cells (DC), however, may increase the chances of preparing effective "vaccines" against these tumours. We show that vaccination with DC pulsed with a tumour lysate considerably increases survival in mice bearing intracranial glioblastomas. These results support the development of DC-based clinical trials for patients with glioblastomas that do not respond to standard therapies.

KW - Dendritic cells

KW - Glioma

KW - Immunotherapy

UR - http://www.scopus.com/inward/record.url?scp=18344364315&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18344364315&partnerID=8YFLogxK

U2 - 10.1007/s10072-005-0405-x

DO - 10.1007/s10072-005-0405-x

M3 - Article

C2 - 15883693

AN - SCOPUS:18344364315

VL - 26

JO - Neurological Sciences

JF - Neurological Sciences

SN - 1590-1874

IS - SUPPL. 1

ER -

Access to Document

10.1007/s10072-005-0405-x