Cell therapies in neuro-oncology

S. Pellegatta, G. Finocchiaro

Research output: Contribution to journalArticlepeer-review

Abstract

During their growth, malignant gliomas interact with the immune system and are able to escape immune reactions. Attempts to instruct the immune system to develop anti-glioma reactions have been partly unsuccessful. Recent advances in the molecular and cellular biology of dendritic cells (DC), however, may increase the chances of preparing effective "vaccines" against these tumours. We show that vaccination with DC pulsed with a tumour lysate considerably increases survival in mice bearing intracranial glioblastomas. These results support the development of DC-based clinical trials for patients with glioblastomas that do not respond to standard therapies.

Original languageEnglish
JournalNeurological Sciences
Volume26
Issue numberSUPPL. 1
DOIs
Publication statusPublished - May 2005

Keywords

  • Dendritic cells
  • Glioma
  • Immunotherapy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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