Cell therapies in neuro-oncology

S. Pellegatta; G. Finocchiaro

doi:10.1007/s10072-005-0405-x

Cell therapies in neuro-oncology

S. Pellegatta, G. Finocchiaro

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article › peer-review

Abstract

During their growth, malignant gliomas interact with the immune system and are able to escape immune reactions. Attempts to instruct the immune system to develop anti-glioma reactions have been partly unsuccessful. Recent advances in the molecular and cellular biology of dendritic cells (DC), however, may increase the chances of preparing effective "vaccines" against these tumours. We show that vaccination with DC pulsed with a tumour lysate considerably increases survival in mice bearing intracranial glioblastomas. These results support the development of DC-based clinical trials for patients with glioblastomas that do not respond to standard therapies.

Original language	English
Journal	Neurological Sciences
Volume	26
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1007/s10072-005-0405-x
Publication status	Published - May 2005

Keywords

Dendritic cells
Glioma
Immunotherapy

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

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10.1007/s10072-005-0405-x

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Cell therapies in neuro-oncology

Abstract

Keywords

ASJC Scopus subject areas

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