Cell-type specificity of mGluR activation in striatal neuronal subtypes

A. Pisani, G. Bernardi, P. Bonsi, D. Centonze, P. Giacomini, P. Calabresi

Research output: Contribution to journalArticle

Abstract

The effects of metabotropic glutamate receptor (mGluR) activation were studied in medium spiny neurons and large aspiny (LA) interneurons by means of electrophysiological and optical recordings. DCG-IV and L-SOP, agonists for group II and III mGluRS, respectively, produced a presynaptic inhibitory effect on corticostriatal glutamatergic excitatory postsynaptic potentials (EPSPs) in both spiny and LA cells. ActivatiOn of group I mGluRs by the selective agonist 3,5-DHPG produced no effect on membrane properties and glutamatergic transmission in spiny neurons, whereas it did cause a membrane depolarization in LA interneurons coupled to increased input resistance. In combined optical and electrophysiological experiments, in spiny neurons 3,5-DHPG enhanced membrane depolarization and intracellular calcium (Ca2+) levels induced by NMDA applications, but not in LA interneurons. These data suggest the existence of a positive interaction between NMDA and group I mGlu receptors only in medium spiny cells which might, at least partially, account for the differential vulnerability to excitotoxic damage observed in striatal neuronal subtypes.

Original languageEnglish
Pages (from-to)119-129
Number of pages11
JournalAmino Acids
Volume19
Issue number1
DOIs
Publication statusPublished - 2000

Keywords

  • Amino acids
  • Electrophysiology
  • Excitotoxicity
  • Metabotropic glutamate receptors
  • Striatum

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry
  • Endocrinology

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