Cell-type specificity of mGluR activation in striatal neuronal subtypes

A. Pisani, G. Bernardi, P. Bonsi, D. Centonze, P. Giacomini, P. Calabresi

Research output: Contribution to journalArticlepeer-review


The effects of metabotropic glutamate receptor (mGluR) activation were studied in medium spiny neurons and large aspiny (LA) interneurons by means of electrophysiological and optical recordings. DCG-IV and L-SOP, agonists for group II and III mGluRS, respectively, produced a presynaptic inhibitory effect on corticostriatal glutamatergic excitatory postsynaptic potentials (EPSPs) in both spiny and LA cells. ActivatiOn of group I mGluRs by the selective agonist 3,5-DHPG produced no effect on membrane properties and glutamatergic transmission in spiny neurons, whereas it did cause a membrane depolarization in LA interneurons coupled to increased input resistance. In combined optical and electrophysiological experiments, in spiny neurons 3,5-DHPG enhanced membrane depolarization and intracellular calcium (Ca2+) levels induced by NMDA applications, but not in LA interneurons. These data suggest the existence of a positive interaction between NMDA and group I mGlu receptors only in medium spiny cells which might, at least partially, account for the differential vulnerability to excitotoxic damage observed in striatal neuronal subtypes.

Original languageEnglish
Pages (from-to)119-129
Number of pages11
JournalAmino Acids
Issue number1
Publication statusPublished - 2000


  • Amino acids
  • Electrophysiology
  • Excitotoxicity
  • Metabotropic glutamate receptors
  • Striatum

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry
  • Endocrinology


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