Cellular aging of skeletal muscle: telomeric and free radical evidence that physical inactivity is responsible and not age.

Massimo Venturelli, Garrett R. Morgan, Anthony J. Donato, Van Reese, Renato Bottura, Cantor Tarperi, Chiara Milanese, Federico Schena, Carlo Reggiani, Fabio Naro, Richard M. Cawthon, Russell S. Richardson

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Telomeres play an essential role in maintaining chromosomal integrity in the face of physiological stressors. Although the age-related shortening of TL (telomere length) in highly proliferative tissue is predominantly due to the replication process, the mechanism for telomere shortening in skeletal muscle, which is minimally proliferative, is unclear. By studying TL in both the upper and lower limbs of the young, old-mobile and old-immobile subjects and by virtue of the bipedal nature of human locomotion, which declines with age, it may be possible to elucidate the mechanism(s) responsible for cellular aging of skeletal muscle. With this approach, we revealed that TL (~15 kb) in arm skeletal muscle is unaffected by age. In contrast TL fell progressively in the legs across the young (~15 kb), the old mobile (~13 kb) and old immobile (~11 kb) subjects. Interestingly, there was a reciprocal increase in leg muscle free radicals across these groups that was correlated with TL (r=0.7), with no such relationship in the arm (r=0.09). Our results document that chronological age does not affect the cellular aging of skeletal muscle, but reveals that physical inactivity, probably mediated by free radicals, has a profound effect upon this process.

Original languageEnglish
Pages (from-to)415-421
Number of pages7
JournalClinical Science
Volume127
Issue number6
DOIs
Publication statusPublished - 2014

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Cell Aging
Telomere
Free Radicals
Skeletal Muscle
Telomere Shortening
Leg
Arm
Locomotion
Lower Extremity
Muscles

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Venturelli, M., Morgan, G. R., Donato, A. J., Reese, V., Bottura, R., Tarperi, C., ... Richardson, R. S. (2014). Cellular aging of skeletal muscle: telomeric and free radical evidence that physical inactivity is responsible and not age. Clinical Science, 127(6), 415-421. https://doi.org/10.1042/CS20140051

Cellular aging of skeletal muscle : telomeric and free radical evidence that physical inactivity is responsible and not age. / Venturelli, Massimo; Morgan, Garrett R.; Donato, Anthony J.; Reese, Van; Bottura, Renato; Tarperi, Cantor; Milanese, Chiara; Schena, Federico; Reggiani, Carlo; Naro, Fabio; Cawthon, Richard M.; Richardson, Russell S.

In: Clinical Science, Vol. 127, No. 6, 2014, p. 415-421.

Research output: Contribution to journalArticle

Venturelli, M, Morgan, GR, Donato, AJ, Reese, V, Bottura, R, Tarperi, C, Milanese, C, Schena, F, Reggiani, C, Naro, F, Cawthon, RM & Richardson, RS 2014, 'Cellular aging of skeletal muscle: telomeric and free radical evidence that physical inactivity is responsible and not age.', Clinical Science, vol. 127, no. 6, pp. 415-421. https://doi.org/10.1042/CS20140051
Venturelli, Massimo ; Morgan, Garrett R. ; Donato, Anthony J. ; Reese, Van ; Bottura, Renato ; Tarperi, Cantor ; Milanese, Chiara ; Schena, Federico ; Reggiani, Carlo ; Naro, Fabio ; Cawthon, Richard M. ; Richardson, Russell S. / Cellular aging of skeletal muscle : telomeric and free radical evidence that physical inactivity is responsible and not age. In: Clinical Science. 2014 ; Vol. 127, No. 6. pp. 415-421.
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