Cellular and molecular characterization of two cases of castleman's disease, plasma cell variant

Silvio Roncella, Paola Francia Di Celle, Emanuele S G D'amore, Claudio Casoli, Giovanna Cutrona, Carlo Muzzulini, Federico Quaini, Guido Nicolo, Robert Foa, Vito Pistoia

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Abstract

We report the cellular and molecular characterization of two cases of Castleman's disease, plasma cell variant, that differed in their clinical presentation and course. Patient 1 had Castleman's disease in association with Kaposis's sarcoma unrelated to human immunodeficiency virus (HIV) infection and died while he was receiving an aggressive chemotherapeutic regimen for Kaposi's sarcoma. Patient 2 had an isolated retroperitoneal lymphoid mass with an adjacent enlarged limph nodes and his symptoms disappeared completely following the surgical removal of both. Pathologic and immunohistochemical analyses in both cases, revealed that there was a massive infiltration of polyclonal plasma cells in the interfollicular areas of the lymph nodes. Immunoglobulin gene rearrangement studies confirmed the polyclonal nature of B-lineage cells in the involved lymph nodes. Southern blot experiments failed to demonstrate the presence of EBV genome copies in the same lymph nodes. These paradigmatic cases lend further support to the notion that Castleman's disease is an extremely heterogeneous entity.

Original languageEnglish
Pages (from-to)391-396
Number of pages6
JournalLeukemia and Lymphoma
Volume5
Issue number5-6
DOIs
Publication statusPublished - 1991

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Keywords

  • Castleman's disease
  • Immunoglobulin gene rearrangement

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Roncella, S., Di Celle, P. F., D'amore, E. S. G., Casoli, C., Cutrona, G., Muzzulini, C., Quaini, F., Nicolo, G., Foa, R., & Pistoia, V. (1991). Cellular and molecular characterization of two cases of castleman's disease, plasma cell variant. Leukemia and Lymphoma, 5(5-6), 391-396. https://doi.org/10.3109/10428199109067634