Abstract
We report the cellular and molecular characterization of two cases of Castleman's disease, plasma cell variant, that differed in their clinical presentation and course. Patient 1 had Castleman's disease in association with Kaposis's sarcoma unrelated to human immunodeficiency virus (HIV) infection and died while he was receiving an aggressive chemotherapeutic regimen for Kaposi's sarcoma. Patient 2 had an isolated retroperitoneal lymphoid mass with an adjacent enlarged limph nodes and his symptoms disappeared completely following the surgical removal of both. Pathologic and immunohistochemical analyses in both cases, revealed that there was a massive infiltration of polyclonal plasma cells in the interfollicular areas of the lymph nodes. Immunoglobulin gene rearrangement studies confirmed the polyclonal nature of B-lineage cells in the involved lymph nodes. Southern blot experiments failed to demonstrate the presence of EBV genome copies in the same lymph nodes. These paradigmatic cases lend further support to the notion that Castleman's disease is an extremely heterogeneous entity.
| Original language | English |
|---|---|
| Pages (from-to) | 391-396 |
| Number of pages | 6 |
| Journal | Leukemia and Lymphoma |
| Volume | 5 |
| Issue number | 5-6 |
| DOIs | |
| Publication status | Published - 1991 |
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Keywords
- Castleman's disease
- Immunoglobulin gene rearrangement
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research
Cite this
Cellular and molecular characterization of two cases of castleman's disease, plasma cell variant. / Roncella, Silvio; Di Celle, Paola Francia; D'amore, Emanuele S G; Casoli, Claudio; Cutrona, Giovanna; Muzzulini, Carlo; Quaini, Federico; Nicolo, Guido; Foa, Robert; Pistoia, Vito.
In: Leukemia and Lymphoma, Vol. 5, No. 5-6, 1991, p. 391-396.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cellular and molecular characterization of two cases of castleman's disease, plasma cell variant
AU - Roncella, Silvio
AU - Di Celle, Paola Francia
AU - D'amore, Emanuele S G
AU - Casoli, Claudio
AU - Cutrona, Giovanna
AU - Muzzulini, Carlo
AU - Quaini, Federico
AU - Nicolo, Guido
AU - Foa, Robert
AU - Pistoia, Vito
PY - 1991
Y1 - 1991
N2 - We report the cellular and molecular characterization of two cases of Castleman's disease, plasma cell variant, that differed in their clinical presentation and course. Patient 1 had Castleman's disease in association with Kaposis's sarcoma unrelated to human immunodeficiency virus (HIV) infection and died while he was receiving an aggressive chemotherapeutic regimen for Kaposi's sarcoma. Patient 2 had an isolated retroperitoneal lymphoid mass with an adjacent enlarged limph nodes and his symptoms disappeared completely following the surgical removal of both. Pathologic and immunohistochemical analyses in both cases, revealed that there was a massive infiltration of polyclonal plasma cells in the interfollicular areas of the lymph nodes. Immunoglobulin gene rearrangement studies confirmed the polyclonal nature of B-lineage cells in the involved lymph nodes. Southern blot experiments failed to demonstrate the presence of EBV genome copies in the same lymph nodes. These paradigmatic cases lend further support to the notion that Castleman's disease is an extremely heterogeneous entity.
AB - We report the cellular and molecular characterization of two cases of Castleman's disease, plasma cell variant, that differed in their clinical presentation and course. Patient 1 had Castleman's disease in association with Kaposis's sarcoma unrelated to human immunodeficiency virus (HIV) infection and died while he was receiving an aggressive chemotherapeutic regimen for Kaposi's sarcoma. Patient 2 had an isolated retroperitoneal lymphoid mass with an adjacent enlarged limph nodes and his symptoms disappeared completely following the surgical removal of both. Pathologic and immunohistochemical analyses in both cases, revealed that there was a massive infiltration of polyclonal plasma cells in the interfollicular areas of the lymph nodes. Immunoglobulin gene rearrangement studies confirmed the polyclonal nature of B-lineage cells in the involved lymph nodes. Southern blot experiments failed to demonstrate the presence of EBV genome copies in the same lymph nodes. These paradigmatic cases lend further support to the notion that Castleman's disease is an extremely heterogeneous entity.
KW - Castleman's disease
KW - Immunoglobulin gene rearrangement
UR - http://www.scopus.com/inward/record.url?scp=0026334960&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026334960&partnerID=8YFLogxK
U2 - 10.3109/10428199109067634
DO - 10.3109/10428199109067634
M3 - Article
VL - 5
SP - 391
EP - 396
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
SN - 1042-8194
IS - 5-6
ER -