Cellular and molecular pathways linking inflammation and cancer

Chiara Porta, Paola Larghi, Monica Rimoldi, Maria Grazia Totaro, Paola Allavena, Alberto Mantovani, Antonio Sica

Research output: Contribution to journalArticlepeer-review

Abstract

Several experimental and epidemiological evidence indicate that, irrespective of the trigger for the development (chronic infection/inflammation or genetic alteration), a "smouldering" inflammation is associated with the most of, if not all, tumours and supports their progression. Several evidence have highlighted that tumours promote a constant influx of myelomonocytic cells that express inflammatory mediators supporting pro-tumoral functions. Myelomonocytic cells are key orchestrators of cancer-related inflammation associated with proliferation and survival of malignant cells, subversion of adaptive immune response, angiogenesis, stroma remodelling and metastasis formation. Although the connection between inflammation and cancer is unequivocal the mechanistic basis of such association are largely unknown. Recent advances in the understanding of the cellular and molecular pathways involved in cancer-related inflammation as well as their potential relevance as diagnostic, prognostic and therapeutic targets are herein discussed.

Original languageEnglish
Pages (from-to)761-777
Number of pages17
JournalImmunobiology
Volume214
Issue number9-10
DOIs
Publication statusPublished - Sep 2009

Keywords

  • Cancer
  • Cytokines
  • Inflammation
  • MDSCs
  • NF-κB
  • STATs
  • TAMs

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Hematology

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