Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells

Alessandra Eva; Keith C. Robbins; Philip R. Andersen; Alagarsamy Srinivasan; Steven R. Tronick; E. Premkumar Reddy; Nelson W. Ellmore; Angela T. Galen; James A. Lautenberger; Takis S. Papas; Eric H. Westin; Flossie Wong-Staal; Robert C. Gallo; Stuart A. Aaronson

doi:10.1038/295116a0

Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells

Alessandra Eva, Keith C. Robbins, Philip R. Andersen, Alagarsamy Srinivasan, Steven R. Tronick, E. Premkumar Reddy, Nelson W. Ellmore, Angela T. Galen, James A. Lautenberger, Takis S. Papas, Eric H. Westin, Flossie Wong-Staal, Robert C. Gallo, Stuart A. Aaronson

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

Polyadenylated RNAs of certain human tumour cell lines are shown to contain transcripts related to the cell-derived transforming onc genes of molecularly cloned primate, murine or avian transforming retrovirus genomes. Thus, analogues of retroviral transforming genes are both present and frequently expressed in human neoplastic cells.

Original language	English
Pages (from-to)	116-119
Number of pages	4
Journal	Nature
Volume	295
Issue number	5845
DOIs	https://doi.org/10.1038/295116a0
Publication status	Published - 1982

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Eva, A., Robbins, K. C., Andersen, P. R., Srinivasan, A., Tronick, S. R., Reddy, E. P., Ellmore, N. W., Galen, A. T., Lautenberger, J. A., Papas, T. S., Westin, E. H., Wong-Staal, F., Gallo, R. C., & Aaronson, S. A. (1982). Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells. Nature, 295(5845), 116-119. https://doi.org/10.1038/295116a0

Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells. / Eva, Alessandra; Robbins, Keith C.; Andersen, Philip R.; Srinivasan, Alagarsamy; Tronick, Steven R.; Reddy, E. Premkumar; Ellmore, Nelson W.; Galen, Angela T.; Lautenberger, James A.; Papas, Takis S.; Westin, Eric H.; Wong-Staal, Flossie; Gallo, Robert C.; Aaronson, Stuart A.

In: Nature, Vol. 295, No. 5845, 1982, p. 116-119.

Research output: Contribution to journal › Article › peer-review

Eva, Alessandra ; Robbins, Keith C. ; Andersen, Philip R. ; Srinivasan, Alagarsamy ; Tronick, Steven R. ; Reddy, E. Premkumar ; Ellmore, Nelson W. ; Galen, Angela T. ; Lautenberger, James A. ; Papas, Takis S. ; Westin, Eric H. ; Wong-Staal, Flossie ; Gallo, Robert C. ; Aaronson, Stuart A. / Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells. In: Nature. 1982 ; Vol. 295, No. 5845. pp. 116-119.

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abstract = "Polyadenylated RNAs of certain human tumour cell lines are shown to contain transcripts related to the cell-derived transforming onc genes of molecularly cloned primate, murine or avian transforming retrovirus genomes. Thus, analogues of retroviral transforming genes are both present and frequently expressed in human neoplastic cells.",

author = "Alessandra Eva and Robbins, {Keith C.} and Andersen, {Philip R.} and Alagarsamy Srinivasan and Tronick, {Steven R.} and Reddy, {E. Premkumar} and Ellmore, {Nelson W.} and Galen, {Angela T.} and Lautenberger, {James A.} and Papas, {Takis S.} and Westin, {Eric H.} and Flossie Wong-Staal and Gallo, {Robert C.} and Aaronson, {Stuart A.}",

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AU - Eva, Alessandra

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AU - Tronick, Steven R.

AU - Reddy, E. Premkumar

AU - Ellmore, Nelson W.

AU - Galen, Angela T.

AU - Lautenberger, James A.

AU - Papas, Takis S.

AU - Westin, Eric H.

AU - Wong-Staal, Flossie

AU - Gallo, Robert C.

AU - Aaronson, Stuart A.

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Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells

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