Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells

Alessandra Eva, Keith C. Robbins, Philip R. Andersen, Alagarsamy Srinivasan, Steven R. Tronick, E. Premkumar Reddy, Nelson W. Ellmore, Angela T. Galen, James A. Lautenberger, Takis S. Papas, Eric H. Westin, Flossie Wong-Staal, Robert C. Gallo, Stuart A. Aaronson

Research output: Contribution to journalArticlepeer-review

Abstract

Polyadenylated RNAs of certain human tumour cell lines are shown to contain transcripts related to the cell-derived transforming onc genes of molecularly cloned primate, murine or avian transforming retrovirus genomes. Thus, analogues of retroviral transforming genes are both present and frequently expressed in human neoplastic cells.

Original languageEnglish
Pages (from-to)116-119
Number of pages4
JournalNature
Volume295
Issue number5845
DOIs
Publication statusPublished - 1982

ASJC Scopus subject areas

  • General

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