Cellular genetic therapy

F. Del Vecchio, A. Filareto, P. Spitalieri, F. Sangiuolo, G. Novelli

Research output: Contribution to journalArticle

Abstract

Cellular genetic therapy is the ultimate frontier for those pathologies that are consequent to a specific nonfunctional cellular type. A viable cure for there kinds of diseases is the replacement of sick cells with healthy ones, which can be obtained from the same patient or a different donor. In fact, structures can be corrected and strengthened with the introduction of undifferentiated cells within specific target tissues, where they will specialize into the desired cellular types. Furthermore, consequent to the recent results obtained with the transdifferentiation experiments, a process that allows the in vitro differentiation of embryonic and adult stem cells, it has also became clear that many advantages may be obtained from the use of stem cells to produce drugs, vaccines, and therapeutic molecules. Since stem cells can sustain lineage potentials, the capacity for differentiation, and better tolerance for the introduction of exogenous genes, they are also considered as feasible therapeutic vehicles for gene therapy. In fact, it is strongly believed that the combination of cellular genetic and gene therapy approaches will definitely allow the development of new therapeutic strategies as well as the production of totipotent cell lines to be used as experimental models for the cure of genetic disorders.

Original languageEnglish
Pages (from-to)2657-2661
Number of pages5
JournalTransplantation Proceedings
Volume37
Issue number6
DOIs
Publication statusPublished - 2005

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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    Del Vecchio, F., Filareto, A., Spitalieri, P., Sangiuolo, F., & Novelli, G. (2005). Cellular genetic therapy. Transplantation Proceedings, 37(6), 2657-2661. https://doi.org/10.1016/j.transproceed.2005.06.037