Cellular interactions in the pathogenesis of interstitial lung diseases

Gianluca Bagnato, Sergio Harari

Research output: Contribution to journalArticlepeer-review

Abstract

Interstitial lung disease (ILD) encompasses a large and diverse group of pathological conditions that share similar clinical, radiological and pathological manifestations, despite potentially having quite different aetiologies and comorbidities. Idiopathic pulmonary fibrosis (IPF) represents probably the most aggressive form of ILD and systemic sclerosis is a multiorgan fibrotic disease frequently associated with ILD. Although the aetiology of these disorders remains unknown, in this review we analyse the pathogenic mechanisms by cell of interest (fibroblast, fibrocyte, myofibroblast, endothelial and alveolar epithelial cells and immune competent cells). New insights into the complex cellular contributions and interactions will be provided, comparing the role of cell subsets in the pathogenesis of IPF and systemic sclerosis.

Original languageEnglish
Pages (from-to)102-114
Number of pages13
JournalEuropean Respiratory Review
Volume24
Issue number135
DOIs
Publication statusPublished - 2015

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Medicine(all)

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