Cellular mechanisms underlying the adjuvant activity of Candida albicans in a mouse lymphoma model

P. Marconi, A. Cassone, L. Tissi, M. Baccarini, P. Puccetti, E. Garaci, E. Bonmassar, F. Bistoni

Research output: Contribution to journalArticle

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Abstract

Inactivated Candida albicans (CA) possesses strong anti-tumor activity when combined with cytoreductive chemotherapy in a mouse lymphoma model. In the present study, experiments were performed in order to elucidate the mechanism(s) underlying CA immunoadjuvant activity. In vivo chemotherapy studies proved that the synergistic anti-tumor effects were lost in athymic (nu/nu) mice and were also abrogated by radiations. In vitro tests did not suggest a major involvement of natural cytotoxic effectors such as macrophages and natural killer cells nor did CA effects appear to be mediated by induction of interferon. It was concluded that the immunoadjuvant activity of CA largely relies on host responses against tumor-associated transplantation antigens with no major involvement of natural resistance immune mechanisms.

Original languageEnglish
Pages (from-to)483-488
Number of pages6
JournalInternational Journal of Cancer
Volume29
Issue number4
Publication statusPublished - 1982

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Candida albicans
Lymphoma
Immunologic Adjuvants
Drug Therapy
Innate Immunity
Natural Killer Cells
Interferons
Neoplasms
Macrophages
Radiation

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Marconi, P., Cassone, A., Tissi, L., Baccarini, M., Puccetti, P., Garaci, E., ... Bistoni, F. (1982). Cellular mechanisms underlying the adjuvant activity of Candida albicans in a mouse lymphoma model. International Journal of Cancer, 29(4), 483-488.

Cellular mechanisms underlying the adjuvant activity of Candida albicans in a mouse lymphoma model. / Marconi, P.; Cassone, A.; Tissi, L.; Baccarini, M.; Puccetti, P.; Garaci, E.; Bonmassar, E.; Bistoni, F.

In: International Journal of Cancer, Vol. 29, No. 4, 1982, p. 483-488.

Research output: Contribution to journalArticle

Marconi, P, Cassone, A, Tissi, L, Baccarini, M, Puccetti, P, Garaci, E, Bonmassar, E & Bistoni, F 1982, 'Cellular mechanisms underlying the adjuvant activity of Candida albicans in a mouse lymphoma model', International Journal of Cancer, vol. 29, no. 4, pp. 483-488.
Marconi, P. ; Cassone, A. ; Tissi, L. ; Baccarini, M. ; Puccetti, P. ; Garaci, E. ; Bonmassar, E. ; Bistoni, F. / Cellular mechanisms underlying the adjuvant activity of Candida albicans in a mouse lymphoma model. In: International Journal of Cancer. 1982 ; Vol. 29, No. 4. pp. 483-488.
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