Cellular prognostic markers in hepatocellular carcinoma

Luigi Buonaguro, Maria Tagliamonte, Annacarmen Petrizzo, Elvira Damiano, Maria Lina Tornesello, Franco M. Buonaguro

Research output: Contribution to journalArticlepeer-review

Abstract

Hepatocellular carcinoma (HCC) is one of the five big killers worldwide and is frequently associated with chronic hepatitis B and C virus (HBV and HCV) infections. Tumor microenvironment consists of a complex network of cells and factors that plays a key role in the tumor progression and prognosis. This is true also for HCC. Several studies have shown strikingly strong correlation between HCC clinical prognosis and intratumoral infiltration of cells affecting tumor growth, invasion, angiogenesis and metastasis. None of such cells is yet validated for routine diagnostic and prognostic assessment. The present review aims at providing a state-of-the-art of such studies.

Original languageEnglish
Pages (from-to)1591-1598
Number of pages8
JournalFuture Oncology
Volume11
Issue number11
DOIs
Publication statusPublished - Jun 1 2015

Keywords

  • cancer-associated fibroblasts
  • hepatic stellate cells
  • hepatic stem/progenitor cells
  • hepatocellular carcinoma
  • macrophages
  • neutrophils
  • prognostic markers
  • Tregs

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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