Cellular reactions in hip prosthesis loosening.

A. Pizzoferrato, S. Stea, G. Ciapetti, E. Cenni, C. Tarabusi, A. Toni

Research output: Contribution to journalArticlepeer-review


Based on the results obtained in histological examinations carried out on periprosthetic tissues in a large series of cases of prosthetic hip joint explants, the authors analyze the cellular events that may occur in loosening phenomena as compared to what occurs in the paraphysiological repair process that is observed in the stable prosthesis. Like other authors, they believe that the principal role in the mechanism of loosening is played by macrophages which are recalled in a large number, at times together with multinucleate giant cells, at the bone-implant interface, after micromovements of the prosthesis and the formation of wear particles have occurred. The macrophages would be capable of favoring resorption of the periprosthetic bone tissue, producing areas of osteolysis in which the transmission of the mechanical stress of loading is modified. The ensuing prosthetic instability increases wear phenomena, causes a greater amount of osteolysis, and, in a vicious cycle, loss of the relationship between bone and implant, and, thus, prosthetic loosening. Finally, the authors report a hypothesis on the pathogenesis of the phenomenon, based on which non-physiological stress, associated with wear and eventually infection, leads to loosening.

Original languageEnglish
Pages (from-to)337-348
Number of pages12
JournalLa Chirurgia degli organi di movimento
Issue number4
Publication statusPublished - Oct 1992

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Cellular reactions in hip prosthesis loosening.'. Together they form a unique fingerprint.

Cite this