Cellular therapies in organ transplantation

Martin J Hoogduijn, Fadi Issa, Federica Casiraghi, Marlies E J Reinders

Research output: Contribution to journalReview articlepeer-review

Abstract

Cellular therapy is a promising tool for improving the outcome of organ transplantation. Various cell types with different immunoregulatory and regenerative properties may find application for specific transplant rejection or injury-related indications. The current era is crucial for the development of cellular therapies. Preclinical models have demonstrated the feasibility of efficacious cell therapy in transplantation, early clinical trials have shown safety of several of these therapies, and the first steps towards efficacy studies in humans have been made. In this review, we address the current state of the art of cellular therapies in clinical transplantation and discuss monitoring tools and endpoints for these studies.

Original languageEnglish
Pages (from-to)233-244
Number of pages12
JournalTransplant International
Volume34
Issue number2
DOIs
Publication statusPublished - Feb 2021

Keywords

  • Cell- and Tissue-Based Therapy
  • Graft Rejection
  • Humans
  • Mesenchymal Stem Cell Transplantation
  • Mesenchymal Stem Cells
  • Organ Transplantation

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