Cellular volume determination of alginate-entrapped hepatocytes by MRI diffusion measurements

G. Capuani, A. Miccheli, A. Tomassini, L. Falasca, T. Aureli, F. Conti

Research output: Contribution to journalArticle

Abstract

Cellular volume of hepatocytes entrapped in alginate gel beads were evaluated under in vivo conditions in samples having different cell densities by applying mathematical models to the diffusion data obtained by magnetic resonance imaging (MRI). The calculated average volume is in good agreement with the values from the literature - being closer to the data relative to living tissue than to isolated cells. The non invasive characteristics of magnetic resonance imaging make this method particularly well suited to obtain information from the intact system.

Original languageEnglish
Pages (from-to)293-305
Number of pages13
JournalArtificial Cells, Blood Substitutes, and Immobilization Biotechnology
Volume28
Issue number4
Publication statusPublished - Jul 2000

Keywords

  • Alginate
  • Hepatocytes
  • Magnetic resonance imaging
  • Water diffusion

ASJC Scopus subject areas

  • Biomedical Engineering
  • Hematology
  • Biotechnology
  • Biomaterials

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