TY - JOUR
T1 - Cellulose nanocrystals
T2 - A multimodal tool to enhance the targeted drug delivery against bone disorders
AU - Zoia, Luca
AU - Morelli, Annalisa
AU - Talamini, Laura
AU - Violatto, Martina B.
AU - Lovati, Arianna B.
AU - Lopa, Silvia
AU - Recordati, Camilla
AU - Toffanin, Chiara
AU - Salanti, Anika
AU - Russo, Luca
AU - Colombo, Laura
AU - Moretti, Matteo
AU - Salmona, Mario
AU - Ferla, Barbara La
AU - Bigini, Paolo
N1 - Funding Information:
This work was partially funded by the Italian Ministry of Health (RC2019-L1040) and by H2020-MSCA-ITN-2018 NanoCarb (814236). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.
Publisher Copyright:
© 2020 Future Medicine Ltd.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/8
Y1 - 2020/8
N2 - Aim: We investigated the use of cellulose nanocrystals (CNCs) as drug nanocarriers combining an anti-osteoporotic agent, alendronate (ALN), and an anti-cancer drug, doxorubicin (DOX). Materials & methods: CNC physicochemical characterization, in vivo imaging coupled with histology and in vitro uptake and toxicity assays were carried out. Results: In vivo CNC-ALN did not modify bone tropism and lung penetration, whereas its liver and kidney accumulation was slightly higher compared with CNCs alone. In vitro studies showed that CNC-ALN did not impair ALN's effect on osteoclasts, whereas CNC-DOX confirmed the therapeutic potential against bone metastatic cancer cells. Conclusions: This study provides robust proof of the potential of CNCs as easy, flexible and specific carriers to deliver compounds to the bone.
AB - Aim: We investigated the use of cellulose nanocrystals (CNCs) as drug nanocarriers combining an anti-osteoporotic agent, alendronate (ALN), and an anti-cancer drug, doxorubicin (DOX). Materials & methods: CNC physicochemical characterization, in vivo imaging coupled with histology and in vitro uptake and toxicity assays were carried out. Results: In vivo CNC-ALN did not modify bone tropism and lung penetration, whereas its liver and kidney accumulation was slightly higher compared with CNCs alone. In vitro studies showed that CNC-ALN did not impair ALN's effect on osteoclasts, whereas CNC-DOX confirmed the therapeutic potential against bone metastatic cancer cells. Conclusions: This study provides robust proof of the potential of CNCs as easy, flexible and specific carriers to deliver compounds to the bone.
KW - bone tropism
KW - cellulose nanocrystals
KW - drug-delivery system
KW - surface functionalization
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U2 - 10.2217/nnm-2020-0139
DO - 10.2217/nnm-2020-0139
M3 - Article
C2 - 32914689
AN - SCOPUS:85093894721
VL - 15
SP - 2271
EP - 2285
JO - Nanomedicine
JF - Nanomedicine
SN - 1743-5889
IS - 23
ER -