CENTA as a chromogenic substrate for studying β-lactamases

Carine Bebrone, Catherine Moali, Florence Mahy, Sandrine Rival, Jean Denis Docquier, Gian Maria Rossolini, Jacques Fastrez, Rex F. Pratt, Jean Marie Frère, Moreno Galleni

Research output: Contribution to journalArticle

Abstract

CENTA, a chromogenic cephalosporin, is readily hydrolyzed by β-lactamases of all classes except for the Aeromonas hydrophila metalloenzyme. Although it cannot practically be used for the detection of β-lactamase-producing strains on agar plates, it should be quite useful for kinetic studies and the detection of the enzymes in crude extracts and chromatographic fractions.

Original languageEnglish
Pages (from-to)1868-1871
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume45
Issue number6
DOIs
Publication statusPublished - Jun 2001

ASJC Scopus subject areas

  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'CENTA as a chromogenic substrate for studying β-lactamases'. Together they form a unique fingerprint.

  • Cite this

    Bebrone, C., Moali, C., Mahy, F., Rival, S., Docquier, J. D., Rossolini, G. M., Fastrez, J., Pratt, R. F., Frère, J. M., & Galleni, M. (2001). CENTA as a chromogenic substrate for studying β-lactamases. Antimicrobial Agents and Chemotherapy, 45(6), 1868-1871. https://doi.org/10.1128/AAC.45.6.1868-1871.2001