CENTA as a chromogenic substrate for studying β-lactamases

Carine Bebrone, Catherine Moali, Florence Mahy, Sandrine Rival, Jean Denis Docquier, Gian Maria Rossolini, Jacques Fastrez, Rex F. Pratt, Jean Marie Frère, Moreno Galleni

Research output: Contribution to journalArticlepeer-review


CENTA, a chromogenic cephalosporin, is readily hydrolyzed by β-lactamases of all classes except for the Aeromonas hydrophila metalloenzyme. Although it cannot practically be used for the detection of β-lactamase-producing strains on agar plates, it should be quite useful for kinetic studies and the detection of the enzymes in crude extracts and chromatographic fractions.

Original languageEnglish
Pages (from-to)1868-1871
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Issue number6
Publication statusPublished - Jun 2001

ASJC Scopus subject areas

  • Pharmacology (medical)


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