Centenarians as a model to discover genetic and epigenetic signatures of healthy ageing

Annibale Alessandro Puca, Chiara Spinelli, Giulia Accardi, Francesco Villa, Calogero Caruso

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Centenarians are a model of successful ageing. The data favours the theory that, in order to live to 100, it is mandatory to inherit the right genetic variants from parents or acquire epigenetic variants through the environment. Therefore, the study of epigenetic signatures of healthy ageing is becoming an important aspect to identify the role of chromatin modification in ageing and understand how manage this fine-tuning system. So, according to the concept of developmental plasticity, establishment of a longevity phenotype requires a combination of stochastic and non-stochastic events that modulate the genetic substrate and leads to a different outcome. It can be concluded that centenarians have a more powerful "engine" shaped by evolution, and that the environment, through epigenetic system, is a component influencing outcome.

Original languageEnglish
JournalMechanisms of Ageing and Development
DOIs
Publication statusAccepted/In press - Jan 1 2017

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Epigenomics
Chromatin
Parents
Phenotype

Keywords

  • Ageing
  • Diet
  • Epigenetics
  • Genetics
  • Longevity
  • Stochasticity

ASJC Scopus subject areas

  • Ageing
  • Developmental Biology

Cite this

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AU - Villa, Francesco

AU - Caruso, Calogero

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