Inflammation is generally conceptualized in terms of cells, mediators, and events in the periphery, with no consideration of an influence of the central nervous system (CNS). However, the neuroendocrine peptide α-melanocyte stimulating hormone (α-MSH) is anti-inflammatory when given systemically and this molecule reaches the brain to exert another effect: fever reduction. Tests on mice indicate that α-MSH can act solely within the CNS to inhibit inflammation in the skin. This observation indicates that the central nervous system can inhibit peripheral inflammation via action of α-MSH molecules and it further strengthens the idea of neural/endocrine modulation of the host responses.
- Neuropeptide modulation
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience