Central administration of the peptide α-MSH inhibits inflammation in the skin

James M. Lipton, Anthony Macaluso, Melanie E. Hiltz, Anna Catania

Research output: Contribution to journalArticlepeer-review


Inflammation is generally conceptualized in terms of cells, mediators, and events in the periphery, with no consideration of an influence of the central nervous system (CNS). However, the neuroendocrine peptide α-melanocyte stimulating hormone (α-MSH) is anti-inflammatory when given systemically and this molecule reaches the brain to exert another effect: fever reduction. Tests on mice indicate that α-MSH can act solely within the CNS to inhibit inflammation in the skin. This observation indicates that the central nervous system can inhibit peripheral inflammation via action of α-MSH molecules and it further strengthens the idea of neural/endocrine modulation of the host responses.

Original languageEnglish
Pages (from-to)795-798
Number of pages4
Issue number4
Publication statusPublished - 1991


  • Inflammation
  • Neuroimmunomodulation
  • Neuropeptide modulation
  • α-MSH

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience


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