Central and peripheral dopamine transporter reduction in Parkinson's disease

Francesca R. Buttarelli, Gabriela Capriotti, Clelia Pellicano, Daniela Prosperi, Annapia Circella, Anna Festa, Morena Giovannelli, Anna Tofani, Francesco E. Pontieri, Francesco Scopinaro

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Previous reports showed the reduction of dopamine transporter immunoreactivity in peripheral blood lymphocytes in Parkinson's disease. In this work, we sought to investigate the possible correlation between central and peripheral dopamine transporter immunoreactivity values in a group of 11 drug-naive patients with Parkinson's disease. Methods: Densitometric measurements of dopamine transporter immunoreactivity in peripheral blood lymphocytes was accomplished as described recently, using a monoclonal antidopamine transporter antibody. Dopamine transporter binding in the caudate and putamen nuclei was measured by means of 123 I-fluopane single-photon emission computed tomography in the same patients. Results: The results failed to show any significant correlation between dopamine transporter immunoreactivity in peripheral blood lymphocytes and the caudate or putamen dopamine transporter binding. Moreover, dopamine transporter immunoreactivity in peripheral blood lymphocytes was reduced also in the single patient with normal striatal dopamine transporter binding. Discussion: These results indicate the lack of correlation between central and peripheral dopamine transporter reduction in Parkinson's disease, using the methodologies applied herein. They therefore suggest that the two phenomena are unlikely to share a common pathogenetic mechanism.

Original languageEnglish
Pages (from-to)687-691
Number of pages5
JournalNeurological Research
Volume31
Issue number7
DOIs
Publication statusPublished - Sep 2009

Keywords

  • Dopamine transporter
  • Immunocytochemistry
  • Parkinson's disease
  • Peripheral blood lymphocytes
  • Single-photon emission computed tomography

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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