Central and peripheral nervous system involvement after renal transplantation

B. Lanzillo, D. Russo, A. Perretti, L. Santoro

Research output: Contribution to journalArticlepeer-review


Objective. To detect central and peripheral nervous system (CNS and PNS) involvement in renal transplant patients after a variable period of hemodialysis. Material. Thirteen patients were enrolled (12 males ,1 female) mean age 42.08 ± 13.17 years; mean period of hemodialysis before renal transplantation (RT) was 50.82 ± 45.81 months. Neurophysiological evaluation was performed after a mean period of 244 ± 302 days since transplantation. Method. All patients underwent clinical examination; antidromic sensory conduction velocity (SNCV) in median and sural nerves; orthodromic motor nerve conduction (MNCV) in popliteal and median nerves; lower limb somatosensoryevoked potentials (SEP); and cortical magnetic stimulation (muscle evoked potentials (MEP) were derived from abductor pollicis brevis (APB) and from abductor hallucis (AH). Central motor conduction time (CMCT), MEP threshold to APB, and central silent period (cSP) were evaluated. Results. Deep vibratory sense was the most frequently involved clinical sign (reduced in 63%; mean 10.45″ ± 4.3″). PNS involvement was observed in 61% of the patients. MNCV of popliteal and median nerves were the most affected electrophysiological parameters (in 38% and 69% of the patients, respectively). SNCV was abnormal in 15% of median and sural nerves. Cortical MEP threshold to resting APB muscle was higher in patients than in controls (81.2% vs 57.2%, respectively; P

Original languageEnglish
JournalNeurological Sciences
Issue number4 SUPPL.
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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