TY - JOUR
T1 - Central cardiovascular responses induced by interleukin 1β and tumor necrosis factor α infused into nucleus tractus solitarii, nucleus parabrachialis medialis and third cerebral ventricle of normotensive rats
AU - Mollace, Vincenzo
AU - Muscoli, Carolina
AU - Palma, Ernesto
AU - Iannone, Michelangelo
AU - Granato, Teresa
AU - Nistico, Robert
AU - Rotiroti, Domenicantonio
PY - 2001/11/13
Y1 - 2001/11/13
N2 - The effect of IL-1β and TNFα infused into nucleus tractus solitari (NTS), nucleus parabrachialis medialis (NPBmed) and third cerebral ventricle of normotensive rats on blood pressure (BP) and heart rate (HR) was investigated. Microinfusion of IL-1β and TNFα into the third cerebral ventricle and NPBmed of normotensive rats produced a dose-dependent hypotensive and bradycardic response. A similar cardiovascular response was produced by infusion of IL1β into NTS but not by TNFα. When rats were pre-treated with Escherichia coli lipopolisaccharide (LPS), an enhancement of cardiovascular response elicited by IL-1β and TNFα was found. Thus, IL-1β and TNFα produce cardiovascular responses when infused into specific areas of the CNS. This effect is potentiated by LPS and this may explain the alteration in cardiovascular regulation which can be observed in diseases in which an excess of circulating endotoxins and cytokines may occur.
AB - The effect of IL-1β and TNFα infused into nucleus tractus solitari (NTS), nucleus parabrachialis medialis (NPBmed) and third cerebral ventricle of normotensive rats on blood pressure (BP) and heart rate (HR) was investigated. Microinfusion of IL-1β and TNFα into the third cerebral ventricle and NPBmed of normotensive rats produced a dose-dependent hypotensive and bradycardic response. A similar cardiovascular response was produced by infusion of IL1β into NTS but not by TNFα. When rats were pre-treated with Escherichia coli lipopolisaccharide (LPS), an enhancement of cardiovascular response elicited by IL-1β and TNFα was found. Thus, IL-1β and TNFα produce cardiovascular responses when infused into specific areas of the CNS. This effect is potentiated by LPS and this may explain the alteration in cardiovascular regulation which can be observed in diseases in which an excess of circulating endotoxins and cytokines may occur.
KW - Central cardiovascular regulation
KW - Cytokines
KW - Endotoxiemia
KW - Nucleus parabrachialis medialis
KW - Nucleus tractus solitarii
UR - http://www.scopus.com/inward/record.url?scp=0035856411&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035856411&partnerID=8YFLogxK
U2 - 10.1016/S0304-3940(01)02284-4
DO - 10.1016/S0304-3940(01)02284-4
M3 - Article
C2 - 11698145
AN - SCOPUS:0035856411
VL - 314
SP - 53
EP - 56
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1-2
ER -