TY - JOUR
T1 - Central conduction abnormalities in patients receiving levodopa-carbidopa intestinal gel infusion
AU - Bove, Francesco
AU - Luigetti, Marco
AU - Gallicchio, Lara
AU - Recchia, Valentina
AU - Petruzzellis, Antonella
AU - Di Iorio, Riccardo
AU - Tamma, Filippo
AU - Fasano, Alfonso
PY - 2017/6
Y1 - 2017/6
N2 - In recent years, several studies have reported a relatively high frequency of polyneuropathy in patients with Parkinson’s disease (PD), in particular, in patients receiving levodopa-carbidopa intestinal gel (LCIG) infusion. In spite of the several patients investigated with nerve conduction studies, no study has prospectively explored a possible central nervous system involvement of patients receiving LCIG infusion. We prospectively evaluated eight PD patients receiving LCIG infusion, who underwent neurophysiological evaluations with nerve conduction studies, visual, somatosensory and motor evoked potentials before LCIG infusion, and 1 and 6 months after. At 6 months follow-up, we found significant reduction in sural nerve SNAP amplitude, increase of central sensory conduction time N22-P40, and increases of central motor conduction time recorded from I dorsal interosseous and tibialis anterior. In PD patients with LCIG infusion, we found a subclinical neurophysiological impairment of both peripheral and central nervous system.
AB - In recent years, several studies have reported a relatively high frequency of polyneuropathy in patients with Parkinson’s disease (PD), in particular, in patients receiving levodopa-carbidopa intestinal gel (LCIG) infusion. In spite of the several patients investigated with nerve conduction studies, no study has prospectively explored a possible central nervous system involvement of patients receiving LCIG infusion. We prospectively evaluated eight PD patients receiving LCIG infusion, who underwent neurophysiological evaluations with nerve conduction studies, visual, somatosensory and motor evoked potentials before LCIG infusion, and 1 and 6 months after. At 6 months follow-up, we found significant reduction in sural nerve SNAP amplitude, increase of central sensory conduction time N22-P40, and increases of central motor conduction time recorded from I dorsal interosseous and tibialis anterior. In PD patients with LCIG infusion, we found a subclinical neurophysiological impairment of both peripheral and central nervous system.
KW - Clinical neurophysiology
KW - Electromyography (EMG)
KW - Evoked potentials
KW - Neuropharmacology
KW - Parkinson’s disease
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U2 - 10.1007/s10072-017-3029-z
DO - 10.1007/s10072-017-3029-z
M3 - Article
AN - SCOPUS:85021151454
SP - 1
EP - 4
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
ER -