Central deficiency of β-endorphin in alcohol addicts

A. R. Genazzani, G. Nappi, F. Facchinetti, G. L. Mazzella, D. Parrini, E. Sinforiani, F. Petraglia, F. Savoldi

Research output: Contribution to journalArticlepeer-review


Alcohol addiction may induce its dependence through a mechanism involving opiate receptors and opioid peptides. For these reasons, we measured ACTH, β-lipotropin, and β-endorphin in the plasma and cerebrospinal fluid (CSF) of 29 alcohol addicts and compared these values with those found in 8 normal volunteers. Although no significant differences existed in peripheral concentrations of the 3 peptides, alcohol addicts had β-endorphin levels in CSF (mean ± SE, 29.4 ± 4.5 fmol/ml) that were 3-fold lower than those of the controls (98.4 ± 10.5 fmol/ml; P

Original languageEnglish
Pages (from-to)583-586
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Issue number3
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism


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