Central deficiency of β-endorphin in alcohol addicts

A. R. Genazzani, G. Nappi, F. Facchinetti, G. L. Mazzella, D. Parrini, E. Sinforiani, F. Petraglia, F. Savoldi

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

Alcohol addiction may induce its dependence through a mechanism involving opiate receptors and opioid peptides. For these reasons, we measured ACTH, β-lipotropin, and β-endorphin in the plasma and cerebrospinal fluid (CSF) of 29 alcohol addicts and compared these values with those found in 8 normal volunteers. Although no significant differences existed in peripheral concentrations of the 3 peptides, alcohol addicts had β-endorphin levels in CSF (mean ± SE, 29.4 ± 4.5 fmol/ml) that were 3-fold lower than those of the controls (98.4 ± 10.5 fmol/ml; P

Original languageEnglish
Pages (from-to)583-586
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume55
Issue number3
Publication statusPublished - 1982

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Endorphins
Opioid Peptides
Cerebrospinal fluid
Cerebrospinal Fluid
Alcohols
beta-Lipotropin
Opioid Receptors
Adrenocorticotropic Hormone
Alcoholism
Healthy Volunteers
Peptides
Plasmas

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Genazzani, A. R., Nappi, G., Facchinetti, F., Mazzella, G. L., Parrini, D., Sinforiani, E., ... Savoldi, F. (1982). Central deficiency of β-endorphin in alcohol addicts. Journal of Clinical Endocrinology and Metabolism, 55(3), 583-586.

Central deficiency of β-endorphin in alcohol addicts. / Genazzani, A. R.; Nappi, G.; Facchinetti, F.; Mazzella, G. L.; Parrini, D.; Sinforiani, E.; Petraglia, F.; Savoldi, F.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 55, No. 3, 1982, p. 583-586.

Research output: Contribution to journalArticle

Genazzani, AR, Nappi, G, Facchinetti, F, Mazzella, GL, Parrini, D, Sinforiani, E, Petraglia, F & Savoldi, F 1982, 'Central deficiency of β-endorphin in alcohol addicts', Journal of Clinical Endocrinology and Metabolism, vol. 55, no. 3, pp. 583-586.
Genazzani AR, Nappi G, Facchinetti F, Mazzella GL, Parrini D, Sinforiani E et al. Central deficiency of β-endorphin in alcohol addicts. Journal of Clinical Endocrinology and Metabolism. 1982;55(3):583-586.
Genazzani, A. R. ; Nappi, G. ; Facchinetti, F. ; Mazzella, G. L. ; Parrini, D. ; Sinforiani, E. ; Petraglia, F. ; Savoldi, F. / Central deficiency of β-endorphin in alcohol addicts. In: Journal of Clinical Endocrinology and Metabolism. 1982 ; Vol. 55, No. 3. pp. 583-586.
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