Central diabetes insipidus in children and young adults

Mohamad Maghnie, Gianluca Cosi, Eugenio Genovese, Maria Luisa Manca-Bitti, Amnon Cohen, Silvia Zecca, Carmine Tinelli, Massimo Gallucci, Sergio Bernasconi, Brunetto Boscherini, Francesca Severi, Maurizio Aricò

Research output: Contribution to journalArticle


Background: Central diabetes insipidus is rare in children and young adults, and up to 50 percent of cases are idiopathic. The clinical presentation and the long-term course of this disorder are largely undefined. Methods: We studied all 79 patients with central diabetes insipidus who were seen at four pediatric endocrinology units between 1970 and 1996. There were 37 male and 42 female patients whose median age at diagnosis was 7.0 years (range, 0.1 to 24.8). All patients underwent magnetic resonance imaging (MRI) and periodic studies of anterior pituitary function. The median duration of follow-up was 7.6 years (range, 1.6 to 26.2). Results: The causes of the central diabetes insipidus were Langerhans'-cell histiocytosis in 12 patients, an intracranial tumor in 18 patients, a skull fracture in 2 patients, and autoimmune polyendocrinopathy in 1 patient; 5 patients had familial disease. The cause was considered to be idiopathic in 41 patients (52 percent). In 74 patients (94 percent) the posterior pituitary was not hyperintense on the first MRI scan obtained, and 29 patients (37 percent) had thickening of the pituitary stalk. Eighteen patients had changes in the thickness of the pituitary stalk over time, ranging from normalization (six patients) or a decrease in thickness (one patient) to further thickening (seven patients) or thickening of a previously normal stalk (four patients). Anterior pituitary hormone deficiencies, primarily growth hormone deficiency, were documented in 48 patients (61 percent) a median of 0.6 year (range, 0.1 to 18.0) after the onset of central diabetes insipidus. Conclusions: Most children and young adults with acquired central diabetes insipidus have abnormal findings on MRI scans of the head, which may change over time, and at least half have anterior pituitary hormone deficiencies during follow-up. (C) 2000, Massachusetts Medical Society.

Original languageEnglish
Pages (from-to)998-1007
Number of pages10
JournalNew England Journal of Medicine
Issue number14
Publication statusPublished - Oct 5 2000

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Central diabetes insipidus in children and young adults'. Together they form a unique fingerprint.

  • Cite this

    Maghnie, M., Cosi, G., Genovese, E., Manca-Bitti, M. L., Cohen, A., Zecca, S., Tinelli, C., Gallucci, M., Bernasconi, S., Boscherini, B., Severi, F., & Aricò, M. (2000). Central diabetes insipidus in children and young adults. New England Journal of Medicine, 343(14), 998-1007. https://doi.org/10.1056/NEJM200010053431403