Central effect of yohimbine on sexual behavior in the rat

M. Sala; D. Braida; M. P. Leone; P. Calcaterra; S. Monti; E. Gori

Central effect of yohimbine on sexual behavior in the rat

M. Sala, D. Braida, M. P. Leone, P. Calcaterra, S. Monti, E. Gori

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

A large range of doses of yohimbine (Y) was administered intracerebroventricularly (ICV) (5-100 μg/rat) or intraperitoneally (IP) (0.35-10 mg/kg) to male rats and the effects on sexual, locomotor and general behavior were evaluated. For both routes there was a clear-cut inverted-U effect (stimulating/depressing), calculable as parabolic regressions on the log of administered doses. The maximal stimulating doses (15 μg/rat ICV and 1 mg/kg IP) significantly shortened mount, intromission and ejaculation latencies and the mean interintromission interval. These data indicate the importance of CNS mechanisms in the sexual effect of Y.

Original language	English
Pages (from-to)	165-173
Number of pages	9
Journal	Physiology and Behavior
Volume	47
Issue number	1
Publication status	Published - Jan 1990

Keywords

Central administration
Rat
Sexual behavior
Yohimbine

ASJC Scopus subject areas

Behavioral Neuroscience
Physiology (medical)

Cite this

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AU - Gori, E.

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Central effect of yohimbine on sexual behavior in the rat

Abstract

Keywords

ASJC Scopus subject areas

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