Central effect of yohimbine on sexual behavior in the rat

M. Sala, D. Braida, M. P. Leone, P. Calcaterra, S. Monti, E. Gori

Research output: Contribution to journalArticlepeer-review


A large range of doses of yohimbine (Y) was administered intracerebroventricularly (ICV) (5-100 μg/rat) or intraperitoneally (IP) (0.35-10 mg/kg) to male rats and the effects on sexual, locomotor and general behavior were evaluated. For both routes there was a clear-cut inverted-U effect (stimulating/depressing), calculable as parabolic regressions on the log of administered doses. The maximal stimulating doses (15 μg/rat ICV and 1 mg/kg IP) significantly shortened mount, intromission and ejaculation latencies and the mean interintromission interval. These data indicate the importance of CNS mechanisms in the sexual effect of Y.

Original languageEnglish
Pages (from-to)165-173
Number of pages9
JournalPhysiology and Behavior
Issue number1
Publication statusPublished - Jan 1990


  • Central administration
  • Rat
  • Sexual behavior
  • Yohimbine

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Physiology (medical)


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