Abstract
A large range of doses of yohimbine (Y) was administered intracerebroventricularly (ICV) (5-100 μg/rat) or intraperitoneally (IP) (0.35-10 mg/kg) to male rats and the effects on sexual, locomotor and general behavior were evaluated. For both routes there was a clear-cut inverted-U effect (stimulating/depressing), calculable as parabolic regressions on the log of administered doses. The maximal stimulating doses (15 μg/rat ICV and 1 mg/kg IP) significantly shortened mount, intromission and ejaculation latencies and the mean interintromission interval. These data indicate the importance of CNS mechanisms in the sexual effect of Y.
| Original language | English |
|---|---|
| Pages (from-to) | 165-173 |
| Number of pages | 9 |
| Journal | Physiology and Behavior |
| Volume | 47 |
| Issue number | 1 |
| Publication status | Published - Jan 1990 |
Keywords
- Central administration
- Rat
- Sexual behavior
- Yohimbine
ASJC Scopus subject areas
- Behavioral Neuroscience
- Physiology (medical)
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Sala, M., Braida, D., Leone, M. P., Calcaterra, P., Monti, S., & Gori, E. (1990). Central effect of yohimbine on sexual behavior in the rat. Physiology and Behavior, 47(1), 165-173.