Abstract
A large range of doses of yohimbine (Y) was administered intracerebroventricularly (ICV) (5-100 μg/rat) or intraperitoneally (IP) (0.35-10 mg/kg) to male rats and the effects on sexual, locomotor and general behavior were evaluated. For both routes there was a clear-cut inverted-U effect (stimulating/depressing), calculable as parabolic regressions on the log of administered doses. The maximal stimulating doses (15 μg/rat ICV and 1 mg/kg IP) significantly shortened mount, intromission and ejaculation latencies and the mean interintromission interval. These data indicate the importance of CNS mechanisms in the sexual effect of Y.
Original language | English |
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Pages (from-to) | 165-173 |
Number of pages | 9 |
Journal | Physiology and Behavior |
Volume | 47 |
Issue number | 1 |
Publication status | Published - Jan 1990 |
Keywords
- Central administration
- Rat
- Sexual behavior
- Yohimbine
ASJC Scopus subject areas
- Behavioral Neuroscience
- Physiology (medical)