Central effects of histamine H2-receptor agonists and antagonists on nociception in the rat

C. Netti, F. Guidobono, V. Sibilia, I. Villa, E. Cazzamalli, A. Pecile

Research output: Contribution to journalArticle

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Abstract

The effects of intracerebroventricular injection of histamine H2-receptor agonists (4-methylhistamine, 4-MeH; dimaprit, DIM), H2-antagonists (cimetidine, CIM; ranitidine, RAN; famotidine, FAM) and of the DIM chemical analogue SK&F 91487 on hot-plate latency in rats were examined. Both DIM (0.4-0.8 μmol/rat) and 4-MeH (0.4-0.8 μmol/rat) significantly enhanced the pain threshold, whereas SF&F 91487 (0.8 μmol/rat) had no effect, indicating that DIM antinociception is specifically due to its activity on histamine (HA) receptors. The H2-antagonists CIM (0.8 μmol/rat) and RAN (0.6 μmol/rat) also enhanced the pain threshold, while FAM (0.03 μmol/rat) did not modify pain latency. When injected before 4-MeH, FAM reduced the antinociceptive effect of 4-MeH. These findings suggest that the antinociceptive activity of CIM and RAN is not related to specific blockade of H2-receptors and that the activation of HA-H2-receptors is inhibitory to nociception.

Original languageEnglish
Pages (from-to)247-249
Number of pages3
JournalAgents and Actions
Volume23
Issue number3-4
DOIs
Publication statusPublished - May 1988

Fingerprint

Histamine Agonists
Histamine H2 Antagonists
Nociception
Rats
Histamine H2 Receptors
Pain Threshold
Dimaprit
Famotidine
Histamine Receptors
Ranitidine
Cimetidine
Chemical activation
Pain
Injections

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

Cite this

Central effects of histamine H2-receptor agonists and antagonists on nociception in the rat. / Netti, C.; Guidobono, F.; Sibilia, V.; Villa, I.; Cazzamalli, E.; Pecile, A.

In: Agents and Actions, Vol. 23, No. 3-4, 05.1988, p. 247-249.

Research output: Contribution to journalArticle

Netti, C, Guidobono, F, Sibilia, V, Villa, I, Cazzamalli, E & Pecile, A 1988, 'Central effects of histamine H2-receptor agonists and antagonists on nociception in the rat', Agents and Actions, vol. 23, no. 3-4, pp. 247-249. https://doi.org/10.1007/BF02142554
Netti, C. ; Guidobono, F. ; Sibilia, V. ; Villa, I. ; Cazzamalli, E. ; Pecile, A. / Central effects of histamine H2-receptor agonists and antagonists on nociception in the rat. In: Agents and Actions. 1988 ; Vol. 23, No. 3-4. pp. 247-249.
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