Central hypothyroidism

Consequences in adult life

C. Asteria, L. Persani, P. Beck-Peccoz

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Central hypothyroidism (CH) is a rare cause of hypothyroidism, generally due to either pituitary or hypothalamic defects. On the basis of its etiology, it is possible to distinguish acquired and hereditary forms. Hereditary CH can be isolated or associated with combined pituitary hormone deficiency (CPHD). In the former case, alterations of only two genes, TSHβ and the TRH receptor, have so far been described as responsible for the disorder. In hereditary CH associated with CPHD, inactivating mutations of different pituitary transcription factors (HESX1, PROP-1, POU1F1) have been found involved in the pathogenesis of the disease. Finally, an association between CH and severe obesity has been described in patients with leptin receptor (Leptin-R) mutations. The clinical consequences of CH in adult life vary greatly depending on the etiology, the severity of the thyroid impairment, the extent of the associated hormone deficiencies, and the age of the patient at the time of the onset of the disease. In general, acquired CH is less severe than the congenital form because of the constitutive activity of the wild-type TSH-receptor. Symptoms and signs of thyroid insufficiency are usually milder than those of primary hypothyroidism, and goiter is always absent. In CPHD, most patients have other endocrine manifestations of the disease (growth failure, delayed puberty, adrenal insufficiency, diabetes insipidus) that lead them to seek medical attention before the hypothyroidism becomes severe. Early diagnosis of the congenital form by neonatal screening for hypothyroidism is strongly recommended in order to avoid cretinism. Replacement therapy with L-thyroxine administration has to be established as soon as possible.

Original languageEnglish
Pages (from-to)1263-1269
Number of pages7
JournalJournal of Pediatric Endocrinology and Metabolism
Volume14
Issue numberSUPPL. 5
Publication statusPublished - 2001

Fingerprint

Hypothyroidism
Thyrotropin Receptors
Thyroid Gland
Thyrotropin Releasing Hormone Receptors
Delayed Puberty
Endocrine System Diseases
Leptin Receptors
Neonatal Screening
Congenital Hypothyroidism
Adrenal Insufficiency
Diabetes Insipidus
Mutation
Morbid Obesity
Abdominal Obesity
Goiter
Thyroxine
Signs and Symptoms
Early Diagnosis
Transcription Factors
Hormones

Keywords

  • Combined pituitary hormone deficiency
  • Congenital hypothyroidism
  • Mutations
  • Pituitary transcription factors

ASJC Scopus subject areas

  • Endocrinology
  • Pediatrics, Perinatology, and Child Health

Cite this

Central hypothyroidism : Consequences in adult life. / Asteria, C.; Persani, L.; Beck-Peccoz, P.

In: Journal of Pediatric Endocrinology and Metabolism, Vol. 14, No. SUPPL. 5, 2001, p. 1263-1269.

Research output: Contribution to journalArticle

Asteria, C, Persani, L & Beck-Peccoz, P 2001, 'Central hypothyroidism: Consequences in adult life', Journal of Pediatric Endocrinology and Metabolism, vol. 14, no. SUPPL. 5, pp. 1263-1269.
Asteria, C. ; Persani, L. ; Beck-Peccoz, P. / Central hypothyroidism : Consequences in adult life. In: Journal of Pediatric Endocrinology and Metabolism. 2001 ; Vol. 14, No. SUPPL. 5. pp. 1263-1269.
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