Central motor tract propagation in man: studies with non-invasive, unifocal, scalp stimulation

Paolo M. Rossini, Maria Caramia, Flora Zarola

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Motor-evoked potentials (MEPs) to unifocal, anodal scalp stimulation have been recorded in 45 healthy volunteers from proximal and distal upper limb muscles. Optimal responses were obtained through a pericranial cathode consisting of 6 or more regularly spaced, interconnected plaques whose impedance was carefully balanced with that of a 0.8-cm2 stimulating anode on the scalp. Individual rectangular pulses with threshold intensity (70-86 mA) 100-200 μs in duration, with rise-decay times shorter than 50 μs resulted more efficient in eliciting individual MEPs in the target muscle. The foci of maximal response for hand and shoulder muscles were localized. The scalp-to-cervical cord conduction time along the motor tracts governing the hand muscles was 5.21 ± 0.42 ms. This index was highly correlated with the subject's height and stable in time when repeatedly tested. Collision between orthodromically and antidromically propagated motor impulses was obtained by simultaneous stimulation of scalp and median nerve at wrist. Response facilitation was achieved by means of prestimulus voluntary contraction of the garget muscle, continous vibration of its tendon or scalp stimulation with paired shocks. Facilitation of MEPs was obtained by prestimulating the ipsilateral motor cortex 8-24 ms before the stimulation of the one contralateral to the target muscle. This was considered at least in part mediated by transcallosal connections. An efferent volley secondary to scalp stimulation was recorded for the nerve trunk with the near-nerve technique. Segmental and suprasegmental mechanisms underlying MEP facilitation provoked by phasic and tonic contractions of the target muscle have been investigated.

Original languageEnglish
Pages (from-to)211-225
Number of pages15
JournalBrain Research
Volume415
Issue number2
DOIs
Publication statusPublished - Jul 14 1987

Fingerprint

Scalp
Motor Evoked Potentials
Muscles
Muscle Contraction
Electrodes
Hand
Median Nerve
Motor Cortex
Vibration
Wrist
Electric Impedance
Upper Extremity
Tendons
Shock
Healthy Volunteers

Keywords

  • Facilitation
  • Motoneuron
  • Motor tract stimulation

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Central motor tract propagation in man : studies with non-invasive, unifocal, scalp stimulation. / Rossini, Paolo M.; Caramia, Maria; Zarola, Flora.

In: Brain Research, Vol. 415, No. 2, 14.07.1987, p. 211-225.

Research output: Contribution to journalArticle

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