Abstract
Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder, which confers an increased risk of a wide range of cancers, and malignant tumors are the most common cause of death in individuals with NF1. Although in children with NF1, the most common neoplasms are optic nerve gliomas and brain tumors, an elevated risk of myeloid leukemia and an increased relative risk of acute lymphoblastic leukemia and non-Hodgkin lymphoma were reported. In adults with NF1, the relative risk of brain tumor is 100 times higher than in the general population. Cases of malignant lymphoma occurring in NF1 adult patients have been reported. However, the association between NF1 and lymphoproliferative diseases is still debated. We report a case of CNS primitive lymphoma in an adult patient who resulted positive for NF1 at genetic testing. At present, only one case of CNS lymphoma in an adult patient displaying clinical criteria for NF1 diagnosis has been reported.
| Original language | English |
|---|---|
| Pages (from-to) | 1429-1433 |
| Number of pages | 5 |
| Journal | Neurological Sciences |
| Volume | 33 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Mar 23 2012 |
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Keywords
- Central nervous system lymphoma
- Neurofibromatosis 1
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health
- Dermatology
- Medicine(all)
Cite this
Central nervous system lymphoma occurring in a patient with neurofibromatosis type 1 (von Recklinghausen disease). / Eoli, Marica; Bianchessi, Donata; Di Stefano, Anna Luisa; Prodi, Elena; Anghileri, Elena; Finocchiaro, Gaetano.
In: Neurological Sciences, Vol. 33, No. 6, 23.03.2012, p. 1429-1433.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Central nervous system lymphoma occurring in a patient with neurofibromatosis type 1 (von Recklinghausen disease)
AU - Eoli, Marica
AU - Bianchessi, Donata
AU - Di Stefano, Anna Luisa
AU - Prodi, Elena
AU - Anghileri, Elena
AU - Finocchiaro, Gaetano
PY - 2012/3/23
Y1 - 2012/3/23
N2 - Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder, which confers an increased risk of a wide range of cancers, and malignant tumors are the most common cause of death in individuals with NF1. Although in children with NF1, the most common neoplasms are optic nerve gliomas and brain tumors, an elevated risk of myeloid leukemia and an increased relative risk of acute lymphoblastic leukemia and non-Hodgkin lymphoma were reported. In adults with NF1, the relative risk of brain tumor is 100 times higher than in the general population. Cases of malignant lymphoma occurring in NF1 adult patients have been reported. However, the association between NF1 and lymphoproliferative diseases is still debated. We report a case of CNS primitive lymphoma in an adult patient who resulted positive for NF1 at genetic testing. At present, only one case of CNS lymphoma in an adult patient displaying clinical criteria for NF1 diagnosis has been reported.
AB - Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder, which confers an increased risk of a wide range of cancers, and malignant tumors are the most common cause of death in individuals with NF1. Although in children with NF1, the most common neoplasms are optic nerve gliomas and brain tumors, an elevated risk of myeloid leukemia and an increased relative risk of acute lymphoblastic leukemia and non-Hodgkin lymphoma were reported. In adults with NF1, the relative risk of brain tumor is 100 times higher than in the general population. Cases of malignant lymphoma occurring in NF1 adult patients have been reported. However, the association between NF1 and lymphoproliferative diseases is still debated. We report a case of CNS primitive lymphoma in an adult patient who resulted positive for NF1 at genetic testing. At present, only one case of CNS lymphoma in an adult patient displaying clinical criteria for NF1 diagnosis has been reported.
KW - Central nervous system lymphoma
KW - Neurofibromatosis 1
UR - http://www.scopus.com/inward/record.url?scp=84883535194&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84883535194&partnerID=8YFLogxK
U2 - 10.1007/s10072-011-0886-8
DO - 10.1007/s10072-011-0886-8
M3 - Article
VL - 33
SP - 1429
EP - 1433
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 6
ER -