Central nervous system marginal zone B-cell lymphoma associated with Chlamydophila psittaci infection

Maurilio Ponzoni, Fausta Bonetti, Pier Luigi Poliani, William Vermi, Chiara Bottelli, Riccardo Dolcetti, Maria Giulia Cangi, Andrés J M Ferreri, Elena Dal Cin, Elisa Pasini, Roberto Liserre, Claudio Doglioni, Giuseppe Rossi, Fabio Facchetti

Research output: Contribution to journalArticlepeer-review


Extranodal marginal zone B-cell lymphomas are linked to bacterial infections that vary according to the anatomical site. The occurrence of these lymphomas in the central nervous system is a very rare event, and the identification of specific bacteria in this setting has not been previously addressed. Herein, we report for the first time a case of primary central nervous system marginal zone B-cell lymphoma involving the choroid plexus associated with Chlamydophila psittaci infection. No concomitant ocular involvement was detected. C psittaci was identified with 3 independent methods, and through immunohistochemistry, it was visualized in the cytoplasm of monocytes/macrophages present within lymphomatous tissues. This observation points toward the opportunity to investigate the prevalence of C psittaci infection in central nervous system lymphomas, particularly in those with low-grade histologic features.

Original languageEnglish
Pages (from-to)738-742
Number of pages5
JournalHuman Pathology
Issue number5
Publication statusPublished - May 2011


  • Central nervous system
  • Chlamydia
  • Infection
  • Lymphoma
  • Marginal zone

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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