Central nervous system neuropeptides after peripheral nerve deafferentation

Alberto E. Panerai, Paola Sacerdote, Anna Brini, Mauro Bianchi, Paolo Mantegazza

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Beta-endorphin, Met-enkephalin, substance P, somatostatin and dynorphin concentrations were evaluated in right and left brain areas, and in cervical, thoracic, and lumbosacral spinal cord of rats that underwent section of either the right, the left, both sciatic nerves, the right brachial plexus, the saphenous, or the sural nerve. With all the surgeries, beta-endorphin concentrations decreased significantly in all brain areas with the exception of the striatum where they did not change. By contrast Met-enkephalin increased in all brain areas and in the spinal cord tracts interested by the lesions. The other peptides were always unaffected. The changes in the concentrations of the neuropeptides were observed starting twenty-four hours after surgery and lasted for at least four months. We did not find a lateralization in the brain peptide concentrations of either sham operated or unilaterally deafferentated rats. Moreover, the treatment with serotoninergic agents normalized the concentrations of beta-endorphin, suggesting a role of the serotoninergic system in the decrease of the peptide that follows the lesion of peripheral nerves.

Original languageEnglish
Pages (from-to)319-324
Number of pages6
JournalPeptides
Volume9
Issue number2
DOIs
Publication statusPublished - 1988

Fingerprint

Neurology
Neuropeptides
Peripheral Nerves
beta-Endorphin
Brain
Central Nervous System
Methionine Enkephalin
Surgery
Peptides
Rats
Spinal Cord
Dynorphins
Sural Nerve
Brachial Plexus
Sciatic Nerve
Substance P
Somatostatin
Thorax

Keywords

  • Deafferentation
  • Lateralization
  • Neuropeptides
  • Serotonin

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Central nervous system neuropeptides after peripheral nerve deafferentation. / Panerai, Alberto E.; Sacerdote, Paola; Brini, Anna; Bianchi, Mauro; Mantegazza, Paolo.

In: Peptides, Vol. 9, No. 2, 1988, p. 319-324.

Research output: Contribution to journalArticle

Panerai, AE, Sacerdote, P, Brini, A, Bianchi, M & Mantegazza, P 1988, 'Central nervous system neuropeptides after peripheral nerve deafferentation', Peptides, vol. 9, no. 2, pp. 319-324. https://doi.org/10.1016/0196-9781(88)90267-7
Panerai, Alberto E. ; Sacerdote, Paola ; Brini, Anna ; Bianchi, Mauro ; Mantegazza, Paolo. / Central nervous system neuropeptides after peripheral nerve deafferentation. In: Peptides. 1988 ; Vol. 9, No. 2. pp. 319-324.
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