Central nervous system relapse in a patient with mantle cell lymphoma in continuous clinical and molecular remission at six years since autografting

M. Ladetto, S. Sametti, M. Astolfi, P. Corradini, I. Ricca, D. Drandi, A. Pileri, C. Tarella

Research output: Contribution to journalArticle

Abstract

Although molecular remissions have been frequently observed and associated with low likelihood of relapse in some lymphoid tumours, they are seldom reported in mantle cell lymphoma (MCL). We performed PCR analysis of a MCL patient with central nervous system (CNS) relapse occurring 76 months after autologous transplantation. Molecular follow-up showed constant absence of PCR-detectable disease, even after the onset of relapse. These data indicate that isolated CNS relapse may occur even after several years of continuous remission and cannot be excluded based on a persistent pattern of molecular remission. However, the prolonged remission duration observed in this patient suggests that achieving PCR-negativity may also be of benefit for MCL patients.

Original languageEnglish
Pages (from-to)679-682
Number of pages4
JournalLeukemia and Lymphoma
Volume40
Issue number5-6
Publication statusPublished - 2001

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Mantle-Cell Lymphoma
Autologous Transplantation
Central Nervous System
Recurrence
Polymerase Chain Reaction
Neoplasms

Keywords

  • Central nervous system relapse
  • Immunoglobulin genes
  • Mantle cell lymphoma
  • Minimal residual disease

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Central nervous system relapse in a patient with mantle cell lymphoma in continuous clinical and molecular remission at six years since autografting. / Ladetto, M.; Sametti, S.; Astolfi, M.; Corradini, P.; Ricca, I.; Drandi, D.; Pileri, A.; Tarella, C.

In: Leukemia and Lymphoma, Vol. 40, No. 5-6, 2001, p. 679-682.

Research output: Contribution to journalArticle

Ladetto, M, Sametti, S, Astolfi, M, Corradini, P, Ricca, I, Drandi, D, Pileri, A & Tarella, C 2001, 'Central nervous system relapse in a patient with mantle cell lymphoma in continuous clinical and molecular remission at six years since autografting', Leukemia and Lymphoma, vol. 40, no. 5-6, pp. 679-682.
Ladetto, M. ; Sametti, S. ; Astolfi, M. ; Corradini, P. ; Ricca, I. ; Drandi, D. ; Pileri, A. ; Tarella, C. / Central nervous system relapse in a patient with mantle cell lymphoma in continuous clinical and molecular remission at six years since autografting. In: Leukemia and Lymphoma. 2001 ; Vol. 40, No. 5-6. pp. 679-682.
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