La tubercolosi del sistema nervoso centrale in bambini non-HIV positivi: l'esperienza di 6 anni di osservazione in un unico centro

Translated title of the contribution: Central nervous system tuberculosis in non-HIV-positive children: A single-center, 6 year experience

L. Nogueira Delfino, G. Fariello, L. Lancella, C. Marabotto, L. Menchini, R. Devito, Y. Errante, C. C. Quattrocchi, D. Longo

Research output: Contribution to journalArticlepeer-review

Abstract

PurposE. The aim of this paper is to describe the imaging features of central nervous system (CNS) tuberculosis on computed tomography (CT) and magnetic resonance imaging (MRI) studies in non-HIV-positive children. Materials and methods. A retrospective descriptive evaluation was conducted on imaging studies obtained from ten children admitted to our hospital over a 6-year period who fulfilled criteria for a diagnosis of CNS tuberculosis. Data were collected with regard to patients' clinical, laboratory and demographic characteristics, as well as results of radiological investigation. Results. We studied ten children, of whom five were boys and five were girls and whose mean age was 4 (range 7 months to16) years. Neuroradiological findings on the first imaging study were basal meningeal enhancement (100%), hydrocephalus (70%), infarcts (90%), tuberculomas (40%) and cranial nerve involvement (20%). Follow-up studies revealed basal meningeal enhancement, hydrocephalus, and infarcts in all patients, tuberculomas in 70% and cranial nerve involvement in 50%. Only one patient showed a pattern of miliary tuberculosis. Conclusions. CNS tuberculosis is still an important cause of childhood morbidity and mortality even in nonimmunosuppressed children. Because prompt diagnosis results in earlier treatment, it is crucial to be aware of tuberculous meningitis and its complications at imaging, especially because of the impact on patients' prognosis.

Translated title of the contributionCentral nervous system tuberculosis in non-HIV-positive children: A single-center, 6 year experience
Original languageItalian
Pages (from-to)669-678
Number of pages10
JournalRadiologia Medica
Volume117
Issue number4
DOIs
Publication statusPublished - Jun 2012

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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