Central opiate modulation of peripheral IL-6 in rats

Magali Bertolucci, Carlo Perego, Maria Grazia De Simoni

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The effect of opiate agonists and antagonists on the induction of serum interleukin-6 (IL-6), an inflammatory cytokine that plays a major role in the acute phase response, was studied. Morphine (10 μg i.c.v. or 15mg kg-1, i.p.), β-endorphin (0.5 or 5 μg, i.c.v.) and etorphin (10 mg kg-1, i.p.) induced IL-6. Moreover, morphine potentiated the IL-6 response induced by IL- 1β (400 ng, i.p. or i.c.v.). When injected intraperitoneally, the opiate antagonist naloxone hydrochloride, antagonized the IL-6 response induced by either i.c.v. or i.p. IL-1β. This effect was not seen with naloxone methiodide, which does not cross the blood-brain barrier. The data show that central opiates are effective modulators of the inflammatory cytokine IL-6.

Original languageEnglish
Pages (from-to)1181-1184
Number of pages4
JournalNeuroReport
Volume7
Issue number6
Publication statusPublished - 1996

Fingerprint

Opiate Alkaloids
Interleukin-6
Interleukin-1
Morphine
Cytokines
Endorphins
Acute-Phase Reaction
Naloxone
Blood-Brain Barrier
Serum

Keywords

  • β- endorphin
  • Central nervous system
  • Etorphin
  • Interleukin-1
  • Interleukin-6
  • Morphine
  • Naloxone

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Bertolucci, M., Perego, C., & De Simoni, M. G. (1996). Central opiate modulation of peripheral IL-6 in rats. NeuroReport, 7(6), 1181-1184.

Central opiate modulation of peripheral IL-6 in rats. / Bertolucci, Magali; Perego, Carlo; De Simoni, Maria Grazia.

In: NeuroReport, Vol. 7, No. 6, 1996, p. 1181-1184.

Research output: Contribution to journalArticle

Bertolucci, M, Perego, C & De Simoni, MG 1996, 'Central opiate modulation of peripheral IL-6 in rats', NeuroReport, vol. 7, no. 6, pp. 1181-1184.
Bertolucci, Magali ; Perego, Carlo ; De Simoni, Maria Grazia. / Central opiate modulation of peripheral IL-6 in rats. In: NeuroReport. 1996 ; Vol. 7, No. 6. pp. 1181-1184.
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