Central precocious puberty: A single blood sample after gonadotropin-releasing hormone agonist administration in monitoring treatment

Mariacarolina Salerno, Salvatore Di Maio, Nicoletta Gasparini, Angela Mariano, Vincenzo Macchia, Alfred Tenore

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

This study was designed to evaluate whether a single blood sample drawn after the home injection of a long-acting gonadotropin-releasing hormone (GnRH) agonist (GnRHa) in patients treated for central precocious puberty (CPP) could be a more simple and inexpensive test with respect to the conventional GnRH stimulating test in assessing adequate suppression of the pituitary-gonadal axis. The response to the first therapeutic injection of the GnRHa triptorelin was studied in 14 newly diagnosed untreated females with CPP. The results were compared with the response that the same patients had to the conventional GnRH stimulation test performed at the time of diagnosis. A significant increase in LH, FSH and E2 levels was observed 12 h after the triptorelin intramuscular injection; serum peak values of LH (70.3 ± 58.5 IU/l), FSH (44.2 ± 21.7 IU/l) and E2 (489.7 ± 263.9 pmol/l) were significantly greater than those obtained with the conventional GnRH test (LH 31.4 ± 21.7, p = 0.002; FSH 19.8 ± 10.7: p = 0.001; E2 83.3 ± 25, p <0.001). In particular, the E2 response, 12 h after triptorelin injection, was clearly consistent with gonadal activation compared to the modest E2 increase in response to the GnRH test. Thereafter 22 girls who were already being treated with triptorelin for CPP were evaluated to see whether a single blood sample drawn 12 h after the therapeutic home injection of GnRHa could be informative in assessing adequate suppression of the pituitary-gonadal axis. This response was also compared to the conventional GnRH stimulation test performed 2 days before the therapeutic triptorelin injection. In 7 girls with evidence of pubertal progression, the E2 response following the GnRHa injection (136.3 ± 44.4 pmol/l) was significantly higher with respect to the response after the GnRH stimulation test (73.0 ± 0.0; p <0.02) indicating an inadequate suppression of the pituitary-gonadal axis. The present data suggest that a single blood sample drawn 12 h after the therapeutic home administration of triptorelin provides a simple, comfortable and inexpensive means of monitoring pituitary as well as gonadal function in girls treated for CPP.

Original languageEnglish
Pages (from-to)205-211
Number of pages7
JournalHormone Research
Volume50
Issue number4
Publication statusPublished - Oct 1998

Fingerprint

Gonadotropin-Releasing Hormone
Triptorelin Pamoate
Injections
Therapeutics
Central Precocious Puberty
Intramuscular Injections
Serum

Keywords

  • Central precocious puberty
  • GnRH agonist, long-acting
  • GnRH stimulation test
  • Triptorelin

ASJC Scopus subject areas

  • Endocrinology

Cite this

Salerno, M., Di Maio, S., Gasparini, N., Mariano, A., Macchia, V., & Tenore, A. (1998). Central precocious puberty: A single blood sample after gonadotropin-releasing hormone agonist administration in monitoring treatment. Hormone Research, 50(4), 205-211.

Central precocious puberty : A single blood sample after gonadotropin-releasing hormone agonist administration in monitoring treatment. / Salerno, Mariacarolina; Di Maio, Salvatore; Gasparini, Nicoletta; Mariano, Angela; Macchia, Vincenzo; Tenore, Alfred.

In: Hormone Research, Vol. 50, No. 4, 10.1998, p. 205-211.

Research output: Contribution to journalArticle

Salerno, M, Di Maio, S, Gasparini, N, Mariano, A, Macchia, V & Tenore, A 1998, 'Central precocious puberty: A single blood sample after gonadotropin-releasing hormone agonist administration in monitoring treatment', Hormone Research, vol. 50, no. 4, pp. 205-211.
Salerno, Mariacarolina ; Di Maio, Salvatore ; Gasparini, Nicoletta ; Mariano, Angela ; Macchia, Vincenzo ; Tenore, Alfred. / Central precocious puberty : A single blood sample after gonadotropin-releasing hormone agonist administration in monitoring treatment. In: Hormone Research. 1998 ; Vol. 50, No. 4. pp. 205-211.
@article{02f04e42d02144498d4a5cee38cf81c4,
title = "Central precocious puberty: A single blood sample after gonadotropin-releasing hormone agonist administration in monitoring treatment",
abstract = "This study was designed to evaluate whether a single blood sample drawn after the home injection of a long-acting gonadotropin-releasing hormone (GnRH) agonist (GnRHa) in patients treated for central precocious puberty (CPP) could be a more simple and inexpensive test with respect to the conventional GnRH stimulating test in assessing adequate suppression of the pituitary-gonadal axis. The response to the first therapeutic injection of the GnRHa triptorelin was studied in 14 newly diagnosed untreated females with CPP. The results were compared with the response that the same patients had to the conventional GnRH stimulation test performed at the time of diagnosis. A significant increase in LH, FSH and E2 levels was observed 12 h after the triptorelin intramuscular injection; serum peak values of LH (70.3 ± 58.5 IU/l), FSH (44.2 ± 21.7 IU/l) and E2 (489.7 ± 263.9 pmol/l) were significantly greater than those obtained with the conventional GnRH test (LH 31.4 ± 21.7, p = 0.002; FSH 19.8 ± 10.7: p = 0.001; E2 83.3 ± 25, p <0.001). In particular, the E2 response, 12 h after triptorelin injection, was clearly consistent with gonadal activation compared to the modest E2 increase in response to the GnRH test. Thereafter 22 girls who were already being treated with triptorelin for CPP were evaluated to see whether a single blood sample drawn 12 h after the therapeutic home injection of GnRHa could be informative in assessing adequate suppression of the pituitary-gonadal axis. This response was also compared to the conventional GnRH stimulation test performed 2 days before the therapeutic triptorelin injection. In 7 girls with evidence of pubertal progression, the E2 response following the GnRHa injection (136.3 ± 44.4 pmol/l) was significantly higher with respect to the response after the GnRH stimulation test (73.0 ± 0.0; p <0.02) indicating an inadequate suppression of the pituitary-gonadal axis. The present data suggest that a single blood sample drawn 12 h after the therapeutic home administration of triptorelin provides a simple, comfortable and inexpensive means of monitoring pituitary as well as gonadal function in girls treated for CPP.",
keywords = "Central precocious puberty, GnRH agonist, long-acting, GnRH stimulation test, Triptorelin",
author = "Mariacarolina Salerno and {Di Maio}, Salvatore and Nicoletta Gasparini and Angela Mariano and Vincenzo Macchia and Alfred Tenore",
year = "1998",
month = "10",
language = "English",
volume = "50",
pages = "205--211",
journal = "Hormone Research",
issn = "0301-0163",
publisher = "S. Karger AG",
number = "4",

}

TY - JOUR

T1 - Central precocious puberty

T2 - A single blood sample after gonadotropin-releasing hormone agonist administration in monitoring treatment

AU - Salerno, Mariacarolina

AU - Di Maio, Salvatore

AU - Gasparini, Nicoletta

AU - Mariano, Angela

AU - Macchia, Vincenzo

AU - Tenore, Alfred

PY - 1998/10

Y1 - 1998/10

N2 - This study was designed to evaluate whether a single blood sample drawn after the home injection of a long-acting gonadotropin-releasing hormone (GnRH) agonist (GnRHa) in patients treated for central precocious puberty (CPP) could be a more simple and inexpensive test with respect to the conventional GnRH stimulating test in assessing adequate suppression of the pituitary-gonadal axis. The response to the first therapeutic injection of the GnRHa triptorelin was studied in 14 newly diagnosed untreated females with CPP. The results were compared with the response that the same patients had to the conventional GnRH stimulation test performed at the time of diagnosis. A significant increase in LH, FSH and E2 levels was observed 12 h after the triptorelin intramuscular injection; serum peak values of LH (70.3 ± 58.5 IU/l), FSH (44.2 ± 21.7 IU/l) and E2 (489.7 ± 263.9 pmol/l) were significantly greater than those obtained with the conventional GnRH test (LH 31.4 ± 21.7, p = 0.002; FSH 19.8 ± 10.7: p = 0.001; E2 83.3 ± 25, p <0.001). In particular, the E2 response, 12 h after triptorelin injection, was clearly consistent with gonadal activation compared to the modest E2 increase in response to the GnRH test. Thereafter 22 girls who were already being treated with triptorelin for CPP were evaluated to see whether a single blood sample drawn 12 h after the therapeutic home injection of GnRHa could be informative in assessing adequate suppression of the pituitary-gonadal axis. This response was also compared to the conventional GnRH stimulation test performed 2 days before the therapeutic triptorelin injection. In 7 girls with evidence of pubertal progression, the E2 response following the GnRHa injection (136.3 ± 44.4 pmol/l) was significantly higher with respect to the response after the GnRH stimulation test (73.0 ± 0.0; p <0.02) indicating an inadequate suppression of the pituitary-gonadal axis. The present data suggest that a single blood sample drawn 12 h after the therapeutic home administration of triptorelin provides a simple, comfortable and inexpensive means of monitoring pituitary as well as gonadal function in girls treated for CPP.

AB - This study was designed to evaluate whether a single blood sample drawn after the home injection of a long-acting gonadotropin-releasing hormone (GnRH) agonist (GnRHa) in patients treated for central precocious puberty (CPP) could be a more simple and inexpensive test with respect to the conventional GnRH stimulating test in assessing adequate suppression of the pituitary-gonadal axis. The response to the first therapeutic injection of the GnRHa triptorelin was studied in 14 newly diagnosed untreated females with CPP. The results were compared with the response that the same patients had to the conventional GnRH stimulation test performed at the time of diagnosis. A significant increase in LH, FSH and E2 levels was observed 12 h after the triptorelin intramuscular injection; serum peak values of LH (70.3 ± 58.5 IU/l), FSH (44.2 ± 21.7 IU/l) and E2 (489.7 ± 263.9 pmol/l) were significantly greater than those obtained with the conventional GnRH test (LH 31.4 ± 21.7, p = 0.002; FSH 19.8 ± 10.7: p = 0.001; E2 83.3 ± 25, p <0.001). In particular, the E2 response, 12 h after triptorelin injection, was clearly consistent with gonadal activation compared to the modest E2 increase in response to the GnRH test. Thereafter 22 girls who were already being treated with triptorelin for CPP were evaluated to see whether a single blood sample drawn 12 h after the therapeutic home injection of GnRHa could be informative in assessing adequate suppression of the pituitary-gonadal axis. This response was also compared to the conventional GnRH stimulation test performed 2 days before the therapeutic triptorelin injection. In 7 girls with evidence of pubertal progression, the E2 response following the GnRHa injection (136.3 ± 44.4 pmol/l) was significantly higher with respect to the response after the GnRH stimulation test (73.0 ± 0.0; p <0.02) indicating an inadequate suppression of the pituitary-gonadal axis. The present data suggest that a single blood sample drawn 12 h after the therapeutic home administration of triptorelin provides a simple, comfortable and inexpensive means of monitoring pituitary as well as gonadal function in girls treated for CPP.

KW - Central precocious puberty

KW - GnRH agonist, long-acting

KW - GnRH stimulation test

KW - Triptorelin

UR - http://www.scopus.com/inward/record.url?scp=0031773861&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031773861&partnerID=8YFLogxK

M3 - Article

C2 - 9838241

AN - SCOPUS:0031773861

VL - 50

SP - 205

EP - 211

JO - Hormone Research

JF - Hormone Research

SN - 0301-0163

IS - 4

ER -