TY - JOUR
T1 - Central precocious puberty in Klinefelter syndrome
T2 - A case report with longitudinal follow-up of growth pattern
AU - Bertelloni, Silvano
AU - Baroncelli, Giampiero I.
AU - Battini, Roberta
AU - Saggese, Giuseppe
PY - 1996/10/2
Y1 - 1996/10/2
N2 - We report idiopathic central precocious puberty in a boy with Klinefelter syndrome and describe the pattern of linear growth and body proportion from the onset of precocious puberty to final height. The patient was not treated for precocious puberty. He reached adequate adult height, for both general population and normative values of Klinefelter syndrome and normal body proportions. We conclude that precocious puberty in Klinefelter syndrome may result in normal body proportion by inducing a major growth spurt of the trunk rather than in the limbs, and that adult height prognosis is not altered by precocious puberty. Given the possible occurrence of precocious puberty in Klinefelter syndrome, we advise a karyotype analysis in boys with sexual precocity, mainly in those who show small rather than enlarged testes.
AB - We report idiopathic central precocious puberty in a boy with Klinefelter syndrome and describe the pattern of linear growth and body proportion from the onset of precocious puberty to final height. The patient was not treated for precocious puberty. He reached adequate adult height, for both general population and normative values of Klinefelter syndrome and normal body proportions. We conclude that precocious puberty in Klinefelter syndrome may result in normal body proportion by inducing a major growth spurt of the trunk rather than in the limbs, and that adult height prognosis is not altered by precocious puberty. Given the possible occurrence of precocious puberty in Klinefelter syndrome, we advise a karyotype analysis in boys with sexual precocity, mainly in those who show small rather than enlarged testes.
KW - body proportion
KW - central precocious puberty
KW - final height
KW - Klinefelter syndrome
KW - linear growth
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U2 - 10.1002/(SICI)1096-8628(19961002)65:1<52::AID-AJMG8>3.0.CO;2-#
DO - 10.1002/(SICI)1096-8628(19961002)65:1<52::AID-AJMG8>3.0.CO;2-#
M3 - Article
C2 - 8914741
AN - SCOPUS:0029795383
VL - 65
SP - 52
EP - 55
JO - American Journal of Medical Genetics, Part A
JF - American Journal of Medical Genetics, Part A
SN - 1552-4825
IS - 1
ER -