Central retinal vein and branch artery occlusion associated with inherited plasminogen deficiency and high lipoprotein(a) levels: A case report

Alessandra Tavola, Silvana Vigano D'Angelo, Francesco Bandello, Rosario Brancato, Mariella Parlavecchia, Omid Safa, Armando D'Angelo

Research output: Contribution to journalArticle

Abstract

We describe a case of central retinal vein and branch artery occlusion associated with inherited type I plasminogen deficiency (68%) and permanent elevation of Lp(a) (460 mg/l, S2 phenotype) in a 45 year old white woman with no associated local or systemic risk factors. Pedigree analysis revealed inheritance of plasminogen deficiency from the deceased father and of high Lp(a) levels from the mother. Both the patient's sons had plasminogen deficiency, but they had normal Lp(a) levels. In a series of 40 consecutive patients with central retinal vein occlusion we previously reported the observation of high Lp(a) levels - consistently associated with the S2 phenotype - in 30% of the patients as compared to a 10% incidence in controls. This case emphasizes the importance of screening patients with occlusion of the retinal vessels and no associated risk factors for coagulation abnormalities predisposing to thrombosis.

Original languageEnglish
Pages (from-to)327-331
Number of pages5
JournalThrombosis Research
Volume80
Issue number4
DOIs
Publication statusPublished - Nov 15 1995

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Keywords

  • lipoprotein(a)
  • plasminogen deficiency
  • retinal artery occlusion
  • retinal vein occlusion

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine

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