TY - JOUR
T1 - Central retinal vein and branch artery occlusion associated with inherited plasminogen deficiency and high lipoprotein(a) levels
T2 - A case report
AU - Tavola, Alessandra
AU - D'Angelo, Silvana Vigano
AU - Bandello, Francesco
AU - Brancato, Rosario
AU - Parlavecchia, Mariella
AU - Safa, Omid
AU - D'Angelo, Armando
PY - 1995/11/15
Y1 - 1995/11/15
N2 - We describe a case of central retinal vein and branch artery occlusion associated with inherited type I plasminogen deficiency (68%) and permanent elevation of Lp(a) (460 mg/l, S2 phenotype) in a 45 year old white woman with no associated local or systemic risk factors. Pedigree analysis revealed inheritance of plasminogen deficiency from the deceased father and of high Lp(a) levels from the mother. Both the patient's sons had plasminogen deficiency, but they had normal Lp(a) levels. In a series of 40 consecutive patients with central retinal vein occlusion we previously reported the observation of high Lp(a) levels - consistently associated with the S2 phenotype - in 30% of the patients as compared to a 10% incidence in controls. This case emphasizes the importance of screening patients with occlusion of the retinal vessels and no associated risk factors for coagulation abnormalities predisposing to thrombosis.
AB - We describe a case of central retinal vein and branch artery occlusion associated with inherited type I plasminogen deficiency (68%) and permanent elevation of Lp(a) (460 mg/l, S2 phenotype) in a 45 year old white woman with no associated local or systemic risk factors. Pedigree analysis revealed inheritance of plasminogen deficiency from the deceased father and of high Lp(a) levels from the mother. Both the patient's sons had plasminogen deficiency, but they had normal Lp(a) levels. In a series of 40 consecutive patients with central retinal vein occlusion we previously reported the observation of high Lp(a) levels - consistently associated with the S2 phenotype - in 30% of the patients as compared to a 10% incidence in controls. This case emphasizes the importance of screening patients with occlusion of the retinal vessels and no associated risk factors for coagulation abnormalities predisposing to thrombosis.
KW - lipoprotein(a)
KW - plasminogen deficiency
KW - retinal artery occlusion
KW - retinal vein occlusion
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U2 - 10.1016/0049-3848(95)00183-R
DO - 10.1016/0049-3848(95)00183-R
M3 - Article
C2 - 8585045
AN - SCOPUS:0028883667
VL - 80
SP - 327
EP - 331
JO - Thrombosis Research
JF - Thrombosis Research
SN - 0049-3848
IS - 4
ER -